Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
604-01-003 ISMRM Abstract

7T post-mortem MRI–histology validation of diffusion metrics for axonal injury in human spinal cord injury

Primary: Neuro - Spinal Cord
Secondary: Diffusion - Simulation/Validation
604-01-003 · Advanced MRI Techniques for Spinal Cord Structure, Function, and Physiology · Thursday, 14 May, 8:30 AM–10:20 AM · Ballroom East
Keywords: Validation Diffusion Tensor Imaging Histology Spinal cord injury White matter microstructure
Accepted
Nikolai I Lesack1,2,3, Sarah R Morris1,2,3, Taylor Swift-LaPointe2, Andrew Yung1,3,4, Kirsten Bale3,4, Shana George1, Andrew Bauman4, Piotr Kozlowski1,2,3,4, Zahra Samadi-Bahrami1,5, Caron Fournier1,5, Pushwant S Mattu6, Kevin Dong1, Femke Streijger1, G. R. Wayne Moore1,5,7, Adam Velenosi1, Veronica Hirsch-Reinshagen1,5,6, Brian K Kwon1,8, Cornelia Laule 1,2,3,5,9
1International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, Canada
2Department of Physics and Astronomy, University of British Columbia, Vancouver, Canada
3Department of Radiology, University of British Columbia, Vancouver, Canada
4UBC MRI Research Centre, University of British Columbia, Vancouver, Canada
5Pathology & Laboratory Medicine, University of British Columbia, Vancouver, Canada
6Vancouver General Hospital, Vancouver, Canada
7Medicine, University of British Columbia, Vancouver, Canada
8Department of Orthopaedics, University of British Columbia, Vancouver, Canada
9University of British Columbia, Vancouver, Canada
Presenting Author: Cornelia Laule

Synopsis

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References

1. [1] W. Ding, S. Hu, P. Wang, et al. “Spinal Cord Injury: The Global Incidence, Prevalence, and Disability From the Global Burden of Disease Study” Spine vol. 47, no. 21, 2022. PMID: 35857624. [pmid]
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5. [5] E. Calabrese, S. M. Adil, G. Cofer, C. S. Perone, J. Cohen-Adad, S. P. Lad and G. A. Johnson, “Postmortem diffusion MRI of the entire human spinal cord at microscopic resolution,” Neuroimage Clinical, vol. 18, p. 963-971, 2018. PMID: 29876281. [pmid]
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9. [9] J. L. R. Andersson, S. Skare and J. Ashburner, "How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging," NeuroImage, vol. 20, pp. 870-888, 2003. PMID: 14568458. [pmid]
10. [10] A. Myronenko and X. Song, "Point-Set Registration: Coherent Point Drift," IEEE Transaction on Pattern Analysis and Machine Intelligence, vol. 32, pp. 2262-2275, 2010. doi:10.1109/TPAMI.2010.46. [doi]
11. [11] G. Sengul, C. Watson, I. Tanaka and G. Paxinos, "Atlas of the spinal cord: Mouse, rat, rhesus, marmoset and human," Elsevier, 2012.
12. [12] A. Samara Et. al., “Neuroinflammation and White Matter Alterations in Obesity Assessed by Diffusion Basis Spectrum Imaging,” Frontiers in Human Neuroscience, vol. 13, 2020. PMID: 31992978. [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/604-01-003