666-01-009 ISMRM Abstract

Optimization of [2-13C]Pyruvate Hyperpolarization Via the Addition of Gadolinium

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)

Secondary: Preclinical Animal & in vitro MR - Probes & Targets

666-01-009 · Hyperpolarization: Novel Methods · Thursday, 14 May, 8:30 AM–9:25 AM · Digital Posters Row G

Keywords: Hyperpolarized MR (Non-Gas) 13C Hyperpolarized 13C MRI Dynamic Nuclear Polarisation

Accepted

Zhuang Liu ¹, Damian Tyler^1,2, Ladislav Valkovič^1,3, James T Grist^1,2,4

¹Oxford Centre for Clinical MR Research (OCMR), University of Oxford, Oxford, United Kingdom

²Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

³Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, Slovakia

⁴Department of Radiology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom

Presenting Author: Zhuang Liu

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References

1. Chung, T. B., Chen, H.-Y., Gordon, J., Mammoli, D., Sriram, R., Autry, W. A., Page, L. M. L., Chaumeil, M. M., Shin, P., Slater, J., Tan, T. C., Suszczynski, C., Chang, S., Li, Y., Bok, A. R., Ronen, M. S., Larson, E. Z. P., Kurhanewicz, J., & Vigneron, B. D. (2019). First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism. Journal of Magnetic Resonance, 309, 106617. https://doi.org/10.1016/j.jmr.2019.106617 [doi]

2. Chen, H., Gordon, J. W., Dwork, N., Chung, B. T., Riselli, A., Sivalokanathan, S., Bok, R. A., Slater, J. B., Vigneron, D. B., Abraham, M. R., & Larson, P. E. Z. (2024). Probing human heart TCA cycle metabolism and response to glucose load using hyperpolarized [2‐13C]pyruvate MRS. NMR in Biomedicine, 37(3). https://doi.org/10.1002/nbm.5074 [doi]

3. Bech, S. K., Hansen, E. S. S., Nielsen, B. R., Wiggers, H., Bengtsen, M. B., Laustsen, C., & Miller, J. J. (2025). Myocardial metabolic flexibility following ketone infusion demonstrated by hyperpolarized [2-13C]pyruvate MRS in pigs. Scientific Reports, 15(1), 5849. https://doi.org/10.1038/s41598-025-90215-9 [doi]

4. Park, J. M., Josan, S., Grafendorfer, T., Yen, Y.-F., Hurd, R. E., Spielman, D. M., & Mayer, D. (2013). Measuring mitochondrial metabolism in rat brain in vivo using MR Spectroscopy of hyperpolarized [2-13C]pyruvate. NMR in Biomedicine, 26(10), 1197–1203. https://doi.org/10.1002/nbm.2935 [doi]

5. Friesen-Waldner, L., Chen, A., Mander, W., Scholl, J. T., & Mckenzie, A. C. (2012). Optimisation of dynamic nuclear polarisation of [1-13C] pyruvate by addition of gadolinium-based contrast agents. Journal of Magnetic Resonance, 223, 85–89. https://doi.org/10.1016/j.jmr.2012.07.010 [doi]

6. Yeung, K., Ravetz, Z., Ng, K. L., AbuEid, G., Hickes, W., Jacob, K., Danisa, M., Durrant, M., Mills, R., Shinozaki, A., McGing, J., Axford, A., Birkhoelzer, S., Schulte, R., Rider, O., McIntyre, A., Fraser, E., Tyler, D., Gleeson, F., & Grist, J. (n.d.). Mapping transmit and receive B1 using variable flip angle acquisition on a person-by-person basis for hyperpolarized Carbon-13 and Xenon-129 MRI. 4498. https://doi.org/10.58530/2023/4498 [doi]

7. Hyacinthe, J.-N., Yeung, K., Lê, T., Tyler, D., Grist, J., & Capozzi, A. (2025, May 10). Optimization of a [1-13C]pyruvic acid sample preparation for clinical hyperpolarization. ISMRM & ISMRT Annual Meeting & Exhibition, Honolulu, Hawaii, USA. https://archive.ismrm.org/2025/4476.html

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/666-01-009