Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
552-03-014 / 552-03-014 ISMRM Abstract

Cerebellar microstructural changes in Essential Tremor and clinical relevance in whole-brain networks: a diffusion MRI study

Primary: Neuro - Other Neurodegeneration
Secondary: Diffusion - DWI/DTI/DKI
552-03-014 · Diffusion Methodologies and Clinical Applications · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 2
552-03-014 · Diffusion Methodologies and Clinical Applications · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 2
Keywords: Cerebellum Diffusion-weighted MRI Neurite orientation dispersion and density imaging Diffusion kurtosis imaging Essential tremor
Accepted
Elena Grosso 1,2, Mélanie Didier1,2, Nadya Pyatigorskaya1,2,3, Jean-François Aubry4, Stéphane Lehéricy1,2,3, Carine Karachi3,5, Elodie Hainque6, Francesca Branzoli7, Cécile Galléa1,6
1Paris Brain Institute - ICM, Inserm U1127, CNRS UMR 7225, Sorbonne Université, UMR S 1127, Paris, France
2Center for Neuroimaging Research (CENIR), Paris Brain Institute, Paris, France
3Sorbonne University, AP-HP, Paris Brain Institute – ICM, Pitié Salpêtrière University Hospital, Paris, France
4Institute Physics for Medicine Paris, Inserm U1273, ESPCI Paris-PSL, CNRS UMR 8361, Paris, France
5AP-HP, Hôpital de la Pitié-Salpêtrière, Service de Neurochirurgie, Paris, France
6Paris Brain Institute - ICM, Team "Movement Investigations and Therapeutics", Paris, France
7Paris Brain Institute - ICM, Inserm U1127, CNRS UMR 7225, Sorbonne Université, UMR S 1127, Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, France
Presenting Author: Elena Grosso

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Louis, Elan D., and Phyllis L. Faust. "Essential tremor pathology: neurodegeneration and reorganization of neuronal connections." Nature Reviews Neurology 16.2 (2020): 69-83.
2. Louis, Elan D., and Joaquim J. Ferreira. "How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor." Movement Disorders 25.5 (2010): 534-541.
3. Louis, Elan D., Eileen Rios, and Claire Henchcliffe. "How are we doing with the treatment of essential tremor (ET)? Persistence of patients with ET on medication: data from 528 patients in three settings." European journal of neurology 17.6 (2010): 882-884
4. Sharifi, Sarvi, et al. "Neuroimaging essentials in essential tremor: a systematic review." NeuroImage: Clinical 5 (2014): 217-231.
5. Alexander, Daniel C., et al. "Imaging brain microstructure with diffusion MRI: practicality and applications." NMR in Biomedicine 32.4 (2019): e3841.
6. Basser, Peter J., and Derek K. Jones. "Diffusion‐tensor MRI: theory, experimental design and data analysis–a technical review." NMR in Biomedicine: An International Journal Devoted to the Development and Application of Magnetic Resonance In Vivo 15.7‐8 (2002): 456-467.
7. Steven, Andrew J., Jiachen Zhuo, and Elias R. Melhem. "Diffusion kurtosis imaging: an emerging technique for evaluating the microstructural environment of the brain." American journal of roentgenology 202.1 (2014): W26-W33.
8. Zhang, Hui, et al. "NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain." Neuroimage 61.4 (2012): 1000-1016.
9. Benito-León, Julián, et al. "White matter microstructural changes are related to cognitive dysfunction in essential tremor." Scientific Reports 7.1 (2017): 2978.
10. Nestrasil, Igor, et al. "White matter measures correlate with essential tremor severity—A pilot diffusion tensor imaging study." Brain and behavior 8.8 (2018): e01039.
11. Martinelli, Paolo, et al. "Diffusion‐weighted imaging study of patients with essential tremor." Movement disorders 22.8 (2007): 1182-1185.
12. Fahn, Stanley, Eduardo Tolosa, and Concepcíon Marín. "Clinical rating scale for tremor." Parkinson’s disease and movement disorders 2 (1993): 271-280.
13. Weyer A, Abele M, Schmitz-Hubsch T, Schoch B, Frings M, Timmann D. Reliability And validity of the scale for the assessment and rating of ataxia: a study in 64 Ataxia patients. Movement Disorders 2007;22:1633–7.
14. Tournier, J-Donald, et al. "MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation." Neuroimage 202 (2019): 116137.
15. Smith, Stephen M., et al. "Advances in functional and structural MR image analysis and implementation as FSL." Neuroimage 23 (2004): S208-S219.
16. Fick, Rutger HJ, Demian Wassermann, and Rachid Deriche. "The Dmipy toolbox: diffusion MRI multi-compartment modeling and microstructure recovery made easy." Frontiers in neuroinformatics 13 (2019): 64.
17. Daducci, Alessandro, et al. "Accelerated microstructure imaging via convex optimization (AMICO) from diffusion MRI data." Neuroimage 105 (2015): 32-44.
18. Diedrichsen, J. et al. (2011) ‘Imaging the deep cerebellar nuclei: A probabilistic atlas and normalization procedure’, NeuroImage, 54(3), pp. 1786–1794. Available at: https://doi.org/10.1016/j.neuroimage.2010.10.035. [doi]
19. Posit team (2025). RStudio: Integrated Development Environment for R. Posit Software, PBC, Boston, MA. URL http://www.posit.co/.
20. Statistical Parametric Mapping: The Analysis of Functional Brain Images, 1st Edition - October 6, 2006, Editors: William D. Penny, Karl J. Friston, John T. Ashburner, Stefan J. Kiebel, Thomas E. Nichols, ISBN: 9781493300952.
21. Patenaude, B. et al. (2011) ‘A Bayesian model of shape and appearance for subcortical brain segmentation’, NeuroImage, 56(3), pp. 907–922. Available at: https://doi.org/10.1016/j.neuroimage.2011.02.046. [doi]
22. S. Mori, S. Wakana, L.M. Nagae-Poetscher, and P.C.M. van Z. (2006) ‘MRI Atlas of Human White Matter’, Journal of Neurosurgery, 195, p. 284.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/552-03-014