Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
605-03-010 ISMRM Abstract

Quantitative Susceptibility Mapping Detects Neuroinflammation-Driven Changes Across the Alzheimer’s Disease Continuum

Primary: Neuro - Alzheimer's Disease
Secondary: Neuro - Dementia
605-03-010 · Next-Generation Neuroimaging for Alzheimer’s Disease: From Molecules to Networks · Thursday, 14 May, 4:00 PM–5:50 PM · Ballroom West
Keywords: Alzheimer's Disease Neuroinflammation Quantitative Susceptibility Mapping (QSM) Immune biomarkers Brain susceptibility
Accepted
Seyyed Ali Hosseini 1, Nesrine Rahmouni1, Stijn Servaes1, Arthur C. Macedo1, Tevy Chan1, Brandon Hall1, Hangwei Zhuang2,3, Junghun Cho3, Sanjeev Chawla4, Yi Wang2,3,5,6, Pedro Rosa‐Neto1
1Integrated Program in Neurosciences, McGill University, Montreal, Canada
2Biomedical Engineering, Cornell University, Ithaca, United States of America
3Department of Radiology, Weill Cornell Medicine, New York, United States of America
4University of Pennsylvania, Philadelphia, United States of America
5Radiology, Weill Cornell Medicine, New York, United States of America
6Department Radiology & Biomedical Engineering, Weill Cornell Medicine, Cornell University, New York, United States of America
Presenting Author: Seyyed Ali Hosseini

Synopsis

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References

1. Heneka MT, et al. Neuroinflammation in Alzheimer’s disease. Lancet Neurol. 2015;14(4):388–405. doi:10.1016/S1474-4422(15)70016-5 [doi]
2. Jack CR Jr, et al. NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 2018;14(4):535–562. doi:10.1016/j.jalz.2018.02.018 [doi]
3. Long HZ, Zhou ZW, Cheng Y, Luo HY, Li FJ, Xu SG, Gao LC. The role of microglia in Alzheimer’s disease from the perspective of immune inflammation and iron metabolism. Front Aging Neurosci. 2022;14:888989. doi:10.3389/fnagi.2022.888989 [doi]
4. Wang Y, Spincemaille P, Liu Z, Dimov A, Deh K, Li J, Zhang Y, Yao Y, Gillen KM, Wilman AH, Gupta A. Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care. J Magn Reson Imaging. 2017;46(4):951–971. doi:10.1002/jmri.25693 [doi]
5. McCarthy RC, Sosa JC, Gardeck AM, Baez AS, Lee CH, Wessling-Resnick M. Inflammation-induced iron transport and metabolism by brain microglia. J Biol Chem. 2018;293(20):7853–7863. doi:10.1074/jbc.RA118.002004 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/605-03-010