562-01-002 ISMRM Abstract

Improving the Repeatability of Corrected 129Xe Red Blood Cell Oscillations Using Patient-Specific Considerations

Primary: Body - Lung

Secondary: Contrast Mechanisms - Hyperpolarized MR (Gas)

562-01-002 · Lung and Thoracic Oncological MRI · Wednesday, 13 May, 8:20 AM–9:15 AM · Digital Posters Row C

Keywords: Hypertension Body Hyperpolarized MR (Gas) MR spectroscopy

Accepted

Zhuchenxin Li¹, Anna Costelle ², David Mummy³, Hong Qin¹, Seth N Lee², Suphachart Leewiwatwong⁴, Bastiaan Driehuys^1,2,4

¹Department of Radiology, Duke University, Durham, United States of America

²Medical Physics Graduate Program, Duke University, Durham, United States of America

³Department of Radiology, Duke University Medical Center, Durham, United States of America

⁴Department of Biomedical Engineering, Duke University, Durham, United States of America

Presenting Author: Anna Costelle

Synopsis

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References

1. Bier EA, Robertson SH, Schrank G, Rackley C, Mammarappallil J, Rajagopal S, McAdams HP, Driehuys B. A protocol for quantifying cardiogenic oscillations in dynamic 129Xe gas exchange spectroscopy: the effects of idiopathic pulmonary fibrosis. NMR in Biomedicine 2019;32(1) doi: 10.1002/nbm.4029 https://doi.org/10.1002/nbm.4029 [doi]

2. Wang Z, Bier EA, Swaminathan A, Parikh K, Nouls J, He M, Mammarappallil JG, Luo S, Driehuys B, Rajagopal S. Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures. European Respiratory Journal 2019;54(6) https://doi.org/10.1183/13993003.00831-2019 [doi]

3. Costelle A, Lu J, Leewiwatwong S, Westerhof B, Mummy D, Rajagopal S, Driehuys B. Combining hyperpolarized 129Xe MR imaging and spectroscopy to noninvasively estimate pulmonary vascular resistance. Journal of Applied Physiology 2025;138(3):623-633. https://doi.org/10.1152/japplphysiol.00440.2024 [doi]

4. Wang Z, Rankine L, Bier EA, Mummy D, Lu J, Church A, Tighe RM, Swaminathan A, Huang YT, Que LG, Mammarappallil JG, Rajagopal S, Driehuys B. Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity. J Appl Physiol (1985). 2021 May 1;130(5):1398-1409. https://doi.org/10.1152/japplphysiol.00702.2020 [doi]

5. Munkholm M, Marott JL, Bjerre-Kristensen L, Madsen F, Pedersen OF, Lange P, Nordestgaard BG, Mortensen J. Reference equations for pulmonary diffusing capacity of carbon monoxide and nitric oxide in adult Caucasians. Eur Respir J. 2018 Jul 19;52(1):1500677. https://doi.org/10.1183/13993003.00677-2015 [doi]

6. Leewiwatwong S, Bechtel A, Mummy D, et al. Establishing standardized healthy reference distributions and values for multisite 129Xe gas exchange MRI/MR spectroscopy at 3 T across major scanner platforms. Magn Reson Med. 2025; 94(4): 1684-1699. https://doi.org/10.1002/mrm.30586 [doi]

7. Niedbalski, P. J. et al. Protocols for multi-site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129Xe MRI clinical trials consortium. Magn Reson Med 86, 2966–2986 (2021). https://doi.org/10.1002/mrm.28985 [doi]

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http://echo.ismrm.org/p/ISMRM2026/562-01-002