Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
464-02-008 ISMRM Abstract

Whole-brain diffusion MRI assessment of microglial morphology in physiological and humanized mouse models.

Primary: Diffusion - DWI/DTI/DKI
Secondary: Diffusion - Microstructure
464-02-008 · Validating Diffusion MRI: Reproducibility, Simulations, and Phantoms · Tuesday, 12 May, 9:15 AM–10:10 AM · Digital Posters Row E
Keywords: Animals DWI/DTI/DKI Microstructure Microbiota
Accepted
Akari Takekoshi 1, Fumiko Seki2, Junichi Hata3, Ikumi Katano4
1Faculty of Health Sciences, Tokyo Metropolitan University, Tokyo, Japan
2BioImaging Center, Central Institute for Experimental Medicine and Life Science, Tokyo, Japan
3Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan
4Department of Medical Innovation, Central Institute for Experimental Medicine and Life Science, Tokyo, Japan
Presenting Author: Akari Takekoshi

Synopsis

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References

1. Eric R. Kandel, John D. Koester, Sarah H. Mack, et al. Principles of Neural Science, 6th Edition. 2022 Sep.
2. Erny D, Hrabě de Angelis AL, Jaitin D, et al. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015 Jul;18(7):965-77. doi: 10.1038/nn.4030. Epub 2015 Jun 1. PMID: 26030851. [doi] [pmid]
3. Garcia-Hernandez R, Cerdán Cerdá A, Trouve Carpena A, et al. Mapping microglia and astrocyte activation in vivo using diffusion MRI. Sci Adv. 2022 May 27;8(21):eabq2923. doi: 10.1126/sciadv.abq2923. Epub 2022 May 27. PMID: 35622913. [doi] [pmid]
4. Gosselin D, Skola D, Coufal NG, et al. An environment-dependent transcriptional network specifies human microglia identity. Science. 2017 Jun 23;356(6344):eaal3222. doi: 10.1126/science.aal3222. Epub 2017 May 25. PMID: 28546318. [doi] [pmid]
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6. Geirsdottir L, David E, Keren-Shaul H, et al. Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program. Cell. 2019 Dec 12;179(7):1609-1622.e16. doi: 10.1016/j.cell.2019.11.010. PMID: 31835035. [doi] [pmid]
7. Carvalho-Paulo D, Bento Torres Neto J, Filho CS, et al. Microglial Morphology Across Distantly Related Species: Phylogenetic, Environmental and Age Influences on Microglia Reactivity and Surveillance States. Front Immunol. 2021 Jun 18;12:683026. doi: 10.3389/fimmu.2021.683026. PMID: 34220831. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/464-02-008