406-02-006 / 271-01-062 ISMRM Abstract

Distinct Hydrodynamic and Hemodynamic Drivers in the Brain Parenchyma Revealed by Multi-modal Dynamic MRI

Primary: Neuro - Neurofluids

Secondary: Diffusion - Diffusion Analysis & Visualization

406-02-006 · The Dynamic Brain: Flow, Pressure, and Exchange · Tuesday, 12 May, 1:40 PM–3:30 PM · Auditorium 2

271-01-062 · ISMRM AMPC Selected Posters · Sunday, 10 May, 7:00 AM–2:00 PM · Traditional Posters

Keywords: Neurofluids Cerebrospinal fluid Fmri Dynamic diffusion-weighted imaging Hypersampling

Accepted

Jianing Zhang¹, Adam M Wright^1,2, Elodie Foster¹, Qiuting Wen ^1,2

¹Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, United States of America

²Weldon School of Biomedical Engineering, Purdue University, West Lafayette, United States of America

Presenting Author: Qiuting Wen

Synopsis

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References

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4. Kiviniemi V., et al., Ultra-fast magnetic resonance encephalography of physiological brain activity–glymphatic pulsation mechanisms? Journal of Cerebral Blood Flow & Metabolism, 2016. 36(6): 1033-1045. DOI: 10.1177/0271678X15622047. [doi]

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8. Wright A.M., et al., HyPER: Region-specific hypersampling of fMRI to resolve low-frequency, respiratory, and cardiac pulsations, revealing age-related differences. Neuroimage, 2025. 321: 121502. DOI: 10.1016/j.neuroimage.2025.121502. [doi]

9. Wen Q., et al., Assessing pulsatile waveforms of paravascular cerebrospinal fluid dynamics within the glymphatic pathways using dynamic diffusion-weighted imaging (dDWI). Neuroimage, 2022. 260: 119464. DOI: 10.1016/j.neuroimage.2022.119464. [doi]

10. Wright A.M., et al., Robust data-driven segmentation of pulsatile cerebral vessels using functional magnetic resonance imaging. Interface Focus, 2024. 14(6): 20240024. DOI: 10.1098/rsfs.2024.0024. [doi]

11. Bedussi B., et al., Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow. J Cereb Blood Flow Metab, 2018. 38(4): 719-726. DOI: 10.1177/0271678X17737984. [doi]

12. Mestre H., et al., Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. Nat Commun, 2018. 9. DOI: ARTN 487810.1038/s41467-018-07318-3.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/406-02-006