Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
567-06-006 ISMRM Abstract

Whole-Brain Mapping of Ethanol Kinetics via 3D SLOW-EPSI at 7 T

Primary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
Secondary: Contrast Mechanisms - Spectroscopy
567-06-006 · Novel Contrast Mechanisms II · Wednesday, 13 May, 4:55 PM–5:50 PM · Digital Posters Row H
Keywords: Brain 7T Spectral editing 3D magnetic resonance spectroscopic imaging Ethanol
Accepted
Guodong Weng 1,2, Piotr Radojewski3,4, Arsany Hakim3, Roland Wiest3,4, Roland Kreis4,5, Johannes Slotboom3,4
1Yale School of Medicine, Department of Radiology & Biomedical Imaging, Yale University, New Haven, United States of America
2Inselspital, University of Bern, Switzerland
3Institute for Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Switzerland
4Translational Imaging Center (TIC), Sitem-Insel, Bern, Switzerland
5Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Switzerland
Presenting Author: Guodong Weng

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References

1. Spielman DM, Glover GH, Macovski A, Pfefferbaum A. Magnetic Resonance Spectroscopic Imaging of Ethanol in the Human Brain: A Feasibility Study. Alcohol Clin Exp Res. 1993;17(5):1072-1077.
2. Sammi MK, Pan JW, Telang FW, et al. Measurements of human brain ethanolT2 by spectroscopic imaging at 4 T. Magn Reson Med. 2000;44(1):35-40.
3. Hetherington HP, Telang F, Pan JW, et al. Spectroscopic imaging of the uptake kinetics of human brain ethanol. Magn Reson Med. 1999;42(6):1019-1026.
4. Hanstock CC, Rothman DL, Shulman RG, Novotny EJ, Petroff OA, Prichard JW. Measurement of ethanol in the human brain using NMR spectroscopy. J Stud Alcohol. 1990;51(2):104-107.
5. Kreis R, Hofmann L, Boesch C. Visibility of the methylene signals of ethanol in 1H-MR spectra of the human brain and implications for model fitting. In: 8th Meeting of ISMRM. 2000:p.426.
6. Kreis R, Mosso J, Weng G, et al. Clues from 1H MR spectroscopy about the cerebral micro-environment of ingested ethanol. In: ISMRM & SMRT Annual Meeting & Exhibition. 2025.
7. Ebel A, Maudsley AA. Improved spectral quality for 3D MR spectroscopic imaging using a high spatial resolution acquisition strategy. Magn Reson Imaging. 2003;21(2):113-120.
8. Weng G, Radojewski P, Sheriff S, et al. SLOW: A novel spectral editing method for whole‐brain MRSI at ultra high magnetic field. Magn Reson Med. 2022;88(1):53-70.
9. Govindaraju V, Meyerhoff DJ, Maudsley AA, Vermathen M, Weiner MW. Effects of brain membranes on 1H nuclear magnetic resonance signal intensity of ethanol in vitro. Alcohol Alcohol. 1997;32(6):671-681.
10. Thierauf-Emberger A, Schuldis D, Dacko M, Lange T. Ethanol Kinetics in the Human Brain Determined by Magnetic Resonance Spectroscopy. Int J Mol Sci. 2023;24(17):13499.
11. FLEMING R. EXPERIMENTAL STUDIES IN ALCOHOLISM. Arch Neurol Psychiatry. 1935;33(3):492.
12. Maudsley AA, Darkazanli A, Alger JR, et al. Comprehensive processing, display and analysis forin vivo MR spectroscopic imaging. NMR Biomed. 2006;19(4):492-503.

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http://echo.ismrm.org/p/ISMRM2026/567-06-006