Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
566-02-009 ISMRM Abstract

Enhancing Diagnosis of FTD and AD: The Impact of Population-Specific Brain Norms and Automated ACE Score Prediction

Primary: Neuro - Dementia
Secondary: Analysis Methods - Classification and Prediction
566-02-009 · MRI Markers of Dementia · Wednesday, 13 May, 9:15 AM–10:10 AM · Digital Posters Row G
Keywords: Neurodegeneration Dementia Normative modeling Indian population Addenbrookes Cognitive Examination (ACE)
Accepted
Punith Bidarakka Venkategowda 1,2, Asha KumaraSwamy Kuppe2, Keerthi Prabhu M2, Lina Bacha3,4,5, Bharath Holla6, Suvarna Alladi7, Faheem Arshad8, Sunil K Khokhar9, Vivek Benegal10, Neelam Sinha11, Tommaso Di Noto3,4,5, Rose Dawn Bharath12,13, Bénédicte Maréchal3,4,5,14
1International Institute of Information Technology Bangalore, Bangalore, India
2Magnetic Resonance, Siemens Healthineers, Bangalore, India
3Swiss Innovation Hub, Siemens Healthineers International AG, Lausanne, Switzerland
4Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
5LTS5, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
6Associate Professor, Integrative medicine, NIMHANS, Bangalore, India
7Professor, Neurology, NIMHANS, Bangalore, India
8Associate Professor, Neurology, NIMHANS, Bangalore, India
9University of Pennsylvania, Philadelphia, United States of America
10Professor, Psychiatry, NIMHANS, Bangalore, India
11Associate Professor, Centre for Brain Research, Indian Institute of Science, Bangalore, India
12Professor, Neuroimaging interventional Radiology, NIMHANS, Bangalore, India
13Equal Contribution, India
14Equal Contribution, Switzerland
Presenting Author: Punith Bidarakka Venkategowda

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References

1. Punith, B. Venkategowda, et al. "Establishing Brain Reference Ranges in Indian Population: Comparison with Westerners and Validation for Parkinsonism Differential.
2. Mioshi, Eneida, et al. "The Addenbrooke's Cognitive Examination Revised (ACE‐R): a brief cognitive test battery for dementia screening." International Journal of Geriatric Psychiatry: A journal of the psychiatry of late life and allied sciences 21.11 (2006): 1078-1085.
3. Defrancesco, Michaela, et al. "Combined cognitive assessment and automated MRI volumetry improves the diagnostic accuracy of detecting MCI due to Alzheimer's disease." Progress in Neuro-Psychopharmacology and Biological Psychiatry 136 (2025): 111157.
4. Cabrera-Martín, María Nieves, et al. "FDG-PET-based neural correlates of Addenbrooke’s cognitive examination III scores in Alzheimer’s disease and frontotemporal degeneration." Frontiers in Psychology 14 (2023): 1273608.
5. Maréchal, Bénédicte, et al. "Use of population-specific atlases for brain morphometry: benefits in Alzheimer’s Disease diagnosis decision support for Chinese patients."
6. Piredda, Gian Franco, et al. "Brain T1 relaxometry changes across the life span: a comparison between two populations." Proceedings of the International Society of Magnetic Resonance in Medicine. Vol. 3792. 2020.
7. Jack Jr, Clifford R., et al. "The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods." Journal of Magnetic Resonance Imaging: An Official Journal of the International Society for Magnetic Resonance in Medicine 27.4 (2008): 685-691.
8. Holla, Bharath, et al. "A series of five population‐specific Indian brain templates and atlases spanning ages 6–60 years." Human brain mapping 41.18 (2020): 5164-5175.
9. Abdi, Hervé. "Partial least square regression (PLS regression)." Encyclopedia for research methods for the social sciences 6.4 (2003): 792-795.
10. Rosen, Howard J., et al. "Patterns of brain atrophy in frontotemporal dementia and semantic dementia." Neurology 58.2 (2002): 198-208.
11. Whitwell, Jennifer L., and Clifford R. Jack Jr. "Comparisons between Alzheimer disease, frontotemporal lobar degeneration, and normal aging with brain mapping." Topics in Magnetic Resonance Imaging 16.6 (2005): 409-425.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/566-02-009