Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
465-01-012 ISMRM Abstract

Exercise-Induced Modulation of Myocardial Substrate Utilization Measured with Hyperpolarized [1-¹³C] Pyruvate CMR

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)
Secondary: Cardiovascular
465-01-012 · Hyperpolarization: Novel Applications · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row F
Keywords: Metabolism Cardiovascular Exercise Metabolic imaging Hyperpolarized MRI
Accepted
Avantika Sinha 1, Anna C Bennett Haller1, Minjie Zhu1, Adam Gaunt2, Donghyun Hong1, Irvane N Kamga1, Erin C Argentieri1, Michael Salerno1, Moriel Vandsburger3, Roselle Abraham4, Peder Larson1
1Department of Radiology and Biomedical Imaging, University Of California, San Francisco (UCSF), United States of America
2General Electric Healthcare, Boston, United States of America
3UC Berkeley, Berkeley, United States of America
4Department of Cardiology, University Of California, San Francisco (UCSF), United States of America
Presenting Author: Avantika Sinha

Synopsis

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References

1. Cunningham CH, Lau JYC, Chen AP, et al. Hyperpolarized 13C Metabolic MRI of the Human Heart: Initial Experience. Circ Res. 2016;119(11):1177-1182. doi:10.1161/CIRCRESAHA.116.309769 [doi]
2. Larson PEZ, Tang S, Liu X, et al. Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge. J Cardiovasc Magn Reson. 2023;25:77. doi:10.1186/s12968-023-00972-7 [doi]
3. Rider OJ, Apps A, Miller JJJJ, et al. Noninvasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized 13C MRI. Circ Res. 2020;126(6):725-736. doi:10.1161/CIRCRESAHA.119.316260 [doi]
4. Tougaard RS, Szocska Hansen ES, Laustsen C, et al. Hyperpolarized [1-13C]pyruvate MRI can image the metabolic shift in cardiac metabolism between the fasted and fed state in a porcine model. Magn Reson Med. 2019;81(4):2655-2665. doi:10.1002/mrm.27560 [doi]
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7. Hyperpolarized-MRI-Toolbox. Available online at: https://github.com/LarsonLab/hyperpolarized-mri-toolbox https://dx.doi.org/10.5281/zenodo.1198915 [doi]
8. Joergensen SH, Hansen ESS, Bøgh N, et al. Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging. J Cardiovasc Magn Reson. 2022;24(1):34. doi:10.1186/s12968-022-00860-6 [doi]
9. Frijia F, Flori A, Giovannetti G, et al. MRI Application and Challenges of Hyperpolarized Carbon-13 Pyruvate in Translational and Clinical Cardiovascular Studies: A Literature Review. Diagnostics. 2024;14(10):1035. doi:10.3390/diagnostics14101035 [doi]
10. Agger P, Hyldebrandt JA, Hansen ESS, et al. Magnetic resonance hyperpolarization imaging detects early myocardial dysfunction in a porcine model of right ventricular heart failure. Eur Heart J - Cardiovasc Imaging. 2020;21(1):93-101. doi:10.1093/ehjci/jez074 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/465-01-012