366-02-014 ISMRM Abstract

White matter dysfunction in patients with ESRD and their association with clinical phenotypes and genomic underpinnings

Primary: Brain Function and fMRI - Functional Connectivity

Secondary: Brain Function and fMRI - fMRI Analysis

366-02-014 · Brain-Body Axis · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row G

Keywords: White Matter Machine learning End-stage renal disease Functional magnetic resonance imaging Allen Human Brain Atlas

Accepted

Peng Li^1,2, ke Bai³, Kuiming Su³, Junya Mu², Ming Zhang ², Wen Wang³

¹Department of Medical Imaging, Nuclear Industry 215 Hospital of Shaanxi Province, Xianyang, China

²Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

³Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, China

Presenting Author: Ming Zhang

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References

1. Viggiano D, Wagner CA, Martino G, Nedergaard M, Zoccali C, Unwin R, Capasso G. Mechanisms of cognitive dysfunction in CKD. Nat Rev Nephrol. 2020 Aug;16(8):452-469. doi: 10.1038/s41581-020-0266-9. [doi]

2. Bugnicourt JM, Godefroy O, Chillon JM, Choukroun G, Massy ZA. Cognitive disorders and dementia in CKD: the neglected kidney-brain axis. J Am Soc Nephrol. 2013 Feb;24(3):353-63. doi: 10.1681/ASN.2012050536. [doi]

3. Andrews TD, Day GS, Irani SR, Kanekiyo T, Hickson LJ. Uremic Toxins, CKD, and Cognitive Dysfunction. J Am Soc Nephrol. 2025 Jun 1;36(6):1208-1226. doi: 10.1681/ASN.0000000675. [doi]

4. Mu J, Chen T, Li P, Ding D, Ma X, Zhang M, Liu J. Altered white matter microstructure mediates the relationship between hemoglobin levels and cognitive control deficits in end-stage renal disease patients. Hum Brain Mapp. 2018 Dec;39(12):4766-4775. doi: 10.1002/hbm.24321. [doi]

5. Mu J, Ma L, Ma S, Ding D, Li P, Ma X, Zhang M, Liu J. Neurological effects of hemodialysis on white matter microstructure in end-stage renal disease. Neuroimage Clin. 2021;31:102743. doi: 10.1016/j.nicl.2021.102743. [doi]

6. Zheng J, Sun Q, Wu X, Dou W, Pan J, Jiao Z, Liu T, Shi H. Brain Micro-Structural and Functional Alterations for Cognitive Function Prediction in the End-Stage Renal Disease Patients Undergoing Maintenance Hemodialysis. Acad Radiol. 2023 Jun;30(6):1047-1055. doi: 10.1016/j.acra.2022.06.019. [doi]

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http://echo.ismrm.org/p/ISMRM2026/366-02-014