Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
331-01-003 / 331-01-003 ISMRM Abstract

Circuit-Specific Motor Restoration by BurstDR Subthalamic Nucleus Deep Brain Stimulation in a Parkinson’s Disease Mouse Model

Primary: Neuro - Parkinson's Disease
Secondary: Preclinical Animal & in vitro MR - Small Animals
331-01-003 · Neuro Imaging and Metabolism · Monday, 11 May, 8:20 AM–10:10 AM · Roof Terrace
331-01-003 · Neuro Imaging and Metabolism · Monday, 11 May, 8:20 AM–10:10 AM · Roof Terrace
Keywords: Parkinson's Disease Deep Brain Stimulation Motor Recovery Intermittent theta burst stimulation BurstDR
Accepted
Ting-Chieh Chen1, Ssu-Ju Li 1, Ching-Wen Chang1, Yao-Wen Liang1, Cheng-Ru Yang1, Yu-Qian Ke1, Yi-Duan Chen2, Yi-Ren Lin3, Zhi-Shin Cheng3, Sheng-Huang Lin4,5, You-Yin Chen1,6
1Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan
2Department of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan
3School of Gerontology and Long-Term Care, Taipei Medical University, Taipei, Taiwan
4Department of Neurology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan
5Department of Neurology, School of Medicine, Tzu Chi University, Hualien, Taiwan
6Ph.D. Program In Medical Neuroscience, Taipei Medical University, Taipei, Taiwan
Presenting Author: Ssu-Ju Li

Synopsis

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References

1. Petersen JJ, Kamp CB, Faltermeier P, et al. Deep brain stimulation for Parkinson’s disease: systematic review with meta-analysis and trial sequential analysis. BMJ medicine. 2024;3(1):e000705.
2. Starr PA, Shivacharan RS, Goldberg E, et al. Five-Year Outcomes from Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson Disease. JAMA neurology. 2025.
3. Herrington TM, Cheng JJ, Eskandar EN. Mechanisms of deep brain stimulation. Journal of neurophysiology. 2016;115(1):19-38.
4. Eisinger RS, Cernera S, Gittis A, Gunduz A, Okun MS. A review of basal ganglia circuits and physiology: application to deep brain stimulation. Parkinsonism & related disorders. 2019;59:9-20.
5. Chakravarthy K, Fishman MA, Zuidema X, Hunter CW, Levy R. Mechanism of action in burst spinal cord stimulation: review and recent advances. Pain Medicine. 2019;20(Supplement_1):S13-S22.
6. Ekstrand MI, Terzioglu M, Galter D, et al. Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proceedings of the National Academy of Sciences. 2007;104(4):1325-1330.
7. Seibenhener ML, Wooten MC. Use of the open field maze to measure locomotor and anxiety-like behavior in mice. Journal of visualized experiments: JoVE. 2015(96).
8. Leger M, Quiedeville A, Bouet V, et al. Object recognition test in mice. Nature Protocols. 2013;8(12):2531-2537.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/331-01-003