Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
552-03-010 / 552-03-010 ISMRM Abstract

DW-pCASL and DTI-ALPS Reveal Blood–Brain Barrier and Glymphatic Dysfunction in Chronic Kidney Disease with Sleep Disturbances

Primary: Brain Function and fMRI - fMRI Analysis
Secondary: Diffusion - Diffusion Acquisition
552-03-010 · Diffusion Methodologies and Clinical Applications · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 2
552-03-010 · Diffusion Methodologies and Clinical Applications · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 2
Keywords: Water exchange Blood brain barrier Chronic Kidney Disease Glymphatic system function Diffusion-weighted ASL
Accepted
Yueyao Chen 1, Qiuyi Chen1, Junfeng Li1, Youjia Zeng2, Fanqi Meng1, Hao dong Qin3, Liantao Hao1, Jinhua Qin1, Hanqing Lv1
1Department of Radiology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China
2Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China
3MR Research Collaboration, Shanghai, China
Presenting Author: Yueyao Chen

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References

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2. Kadry H, Noorani B, Cucullo L. A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity. Fluids Barriers CNS. Nov 18 2020;17(1):69. doi:10.1186/s12987-020-00230-3 [doi]
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7. Schirge PM, Perneczky R, Taoka T, et al. Perivascular space and white matter hyperintensities in Alzheimer's disease: associations with disease progression and cognitive function. Alzheimers Res Ther. Mar 18 2025;17(1):62. doi:10.1186/s13195-025-01707-9 [doi]
8. Kidney Disease: Improving Global Outcomes CKDWG. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. Apr 2024;105(4S):S117-S314. doi:10.1016/j.kint.2023.10.018 [doi]
9. Buysse DJ, Reynolds CF, 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. May 1989;28(2):193-213. doi:10.1016/0165-1781(89)90047-4 [doi]
10. Taoka T, Masutani Y, Kawai H, et al. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases. Japanese journal of radiology. Apr 2017;35(4):172-178. doi:10.1007/s11604-017-0617-z [doi]
11. Liu X, Barisano G, Shao X, et al. Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function. Aging Dis. Aug 1 2024;15(4):1885-1898. doi:10.14336/AD.2023.0321-2 [doi]
12. Ling C, Zhang J, Shao X, et al. Diffusion prepared pseudo-continuous arterial spin labeling reveals blood-brain barrier dysfunction in patients with CADASIL. Eur Radiol. Oct 2023;33(10):6959-6969. doi:10.1007/s00330-023-09652-7 [doi]

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http://echo.ismrm.org/p/ISMRM2026/552-03-010