Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
563-02-012 ISMRM Abstract

Quantitative MRI Characterization of Osteochondritis Dissecans Lesion Development in a Piglet Model

Accepted
Erick O Buko 1,2, Callista Hohenhaus1, Alexandra R Armstrong1, Casey P Johnson, Ferenc Tóth1
1Department of Veterinary Clinical Sciences, University of Minnesota, Minneapolis, United States of America
2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, United States of America
Presenting Author: Erick O Buko

Synopsis

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References

1. Edmonds EW, Polousky J. A review of knowledge in osteochondritis dissecans: 123 years of minimal evolution from Konig to the ROCK study group. Clin Orthop Relat Res. Apr 2013;471(4):1118-26. doi:10.1007/s11999-012-2290-y [doi]
2. Adachi N, Deie M, Nakamae A, Okuhara A, Kamei G, Ochi M. Functional and radiographic outcomes of unstable juvenile osteochondritis dissecans of the knee treated with lesion fixation using bioabsorbable pins. J Pediatr Orthop. Jan 2015;35(1):82-8. doi: 10.1097/BPO.0000000000000226. [doi]
3. Olstad K, Shea KG, Cannamela PC, et al. Juvenile osteochondritis dissecans of the knee is a result of failure of the blood supply to growth cartilage and osteochondrosis. Osteoarthritis Cartilage. Dec 2018;26(12):1691-1698.doi: 10.1016/j.joca.2018.06.019. [doi]
4. Tóth F, Tompkins MA, Shea KG, Ellermann JM, Carlson CS. Identification of Areas of Epiphyseal Cartilage Necrosis at Predilection Sites of Juvenile Osteochondritis Dissecans in Pediatric Cadavers. J Bone Joint Surg Am. Dec 2018;100(24):2132-2139. doi: 10.2106/JBJS.18.00464. [doi]
5. Tóth F, David FH, LaFond E, Wang L, Ellermann JM, Carlson CS. In vivo visualization using MRI T2 mapping of induced osteochondrosis and osteochondritis dissecans lesions in goats undergoing controlled exercise. Journal of Orthopaedic Research. 2017 Apr;35(4):868-75. doi: 10.1002/jor.23332. [doi]
6. Zbýň Š, Santiago C, Johnson CP, Ludwig KD, Zhang L, Marette S, Tompkins MA, Nelson BJ, Takahashi T, Metzger GJ, Carlson CS. Compositional evaluation of lesion and parent bone in patients with juvenile osteochondritis dissecans of the knee using T2* mapping. Journal of Orthopaedic Research®. 2022 Jul;40(7):1632-44. doi: 10.1002/jor.25187. [doi]
7. Kajabi AW, Zbýň Š, Johnson CP, Tompkins MA, Nelson BJ, Takahashi T, Shea KG, Marette S, Carlson CS, Ellermann JM. Longitudinal 3T MRI T2* mapping of Juvenile osteochondritis dissecans (JOCD) lesions differentiates operative from non‐operative patients—Pilot study. Journal of Orthopaedic Research®. 2023 Jan;41(1):150-60. doi: 10.1002/jor.25343. [doi]
8. Armstrong AR, Buko EO, Johnson CP, Tóth F. Longitudinal In Vivo 3T MRI of Naturally Occurring Early Osteochondrosis Lesions in the Piglet Humeral Epiphyseal Cartilage and Growth Plate. Journal of Orthopaedic Research®. 2025 Aug 10. doi: 10.1002/jor.70044. [doi]
9. Ellermann J, Johnson CP, Wang L, Macalena JA, Nelson BJ, LaPrade RF. Insights into the epiphyseal cartilage origin and subsequent osseous manifestation of juvenile osteochondritis dissecans with a modified clinical MR imaging protocol: a pilot study. Radiology. 2017 Mar;282(3):798-806. doi: 10.1148/radiol.2016160071. [doi]
10. Tóth F, Buko EO, Armstrong AR, Johnson CP. Relationship between the extent of vascular injury and the evolution of surgically induced osteochondrosis lesions in a piglet model. PloS one. 2024 Aug 8;19(8):e0308641. doi: 10.1371/journal.pone.0308641. [doi]
11. Hesper T, Hosalkar HS, Bittersohl D, Welsch GH, Krauspe R, Zilkens C, Bittersohl B. T2* mapping for articular cartilage assessment: principles, current applications, and future prospects. Skeletal radiology. 2014 Oct;43(10):1429-45. doi: 10.1007/s00256-014-1852-3. [doi]

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