Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
301-04-004 ISMRM Abstract

Investigation of Dipolar Order Relaxation Times (T1D) and ihMT in Lipid Model Membranes

Primary: Contrast Mechanisms - Magnetization Transfer
Secondary: Contrast Mechanisms - Relaxometry
301-04-004 · Innovations in Contrast Mechanisms for MRI · Monday, 11 May, 4:10 PM–6:00 PM · Hall 1A
Keywords: Relaxometry Inhomogeneous magnetization transfer Dipolar order relaxation Lipid model membranes Jeener-Broekaert measurements
Accepted
Niklas Wallstein 1, Axelle Grélard2, Olivier M Girard1,3, Erick J Dufourc2, Antoine Loquet2, Guillaume Duhamel1,3
1Aix Marseille Univ, Marseille, France
2University of Bordeaux, CNRS, Bordeaux INP, CBMN, UMR, 5248, IECB, Pessac, France
3APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France
Presenting Author: Niklas Wallstein

Synopsis

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References

1. Varma, G., et al. Magnetization transfer from inhomogeneously broadened lines: A potential marker for myelin. Magn. Reson. Med. 73.2 (2015): 614-622. Doi:10.1002/mrm.25174 [doi]
2. Alsop, D. C., et al. Inhomogeneous magnetization transfer imaging: Concepts and directions for further development. NMR in Biomed. 36.6 (2023): e4808. Doi:10.1002/nbm.4808 [doi]
3. Manning, A. P., et al. The physical mechanism of “inhomogeneous” magnetization transfer MRI. J. Magn. Reson. 274 (2017): 125-136. Doi:10.1016/j.jmr.2016.11.013 [doi]
4. Varma, G., et al. Interpretation of magnetization transfer from inhomogeneously broadened lines (ihMT) in tissues as a dipolar order effect within motion restricted molecules. J. Magn. Reson. 260 (2015): 67-76. Doi:10.1016/j.jmr.2015.08.024 [doi]
5. Henkelman, R. M., et al. Quantitative Interpretation of Magnetization-Transfer. Magn. Reson. Med. 29.6 (1993): pp. 759–766. Doi:10.1002/mrm.1910290607 [doi]
6. Provotorov, B. N. Magnetic resonance saturation in crystals. Soviet Physics Jetp-Ussr 14.5 (1962): 1126-1131.
7. Duhamel, G., et al. Validating the sensitivity of inhomogeneous magnetization transfer (ihMT) MRI to myelin with fluorescence microscopy. Neuroimage 199 (2019): 289-303. Doi:10.1016/j.neuroimage.2019.05.061 [doi]
8. Hertanu, A., et al. T1D‐weighted ihMT imaging–part I. Isolation of long‐and short‐T1D components by T1D‐filtering. Magn. Reson.Med. 87.5 (2022): 2313-2328. Doi:10.1002/mrm.29139 [doi]
9. Traïkia, M., et al. Formation of unilamellar vesicles by repetitive freeze-thaw cycles: characterization by electron microscopy and 31P-nuclear magnetic resonance. European Biophysics Journal. (2000): 29(3):184-195. Doi:10.1007/s002490000077 [doi]
10. Wallstein, N., et al. Dipolar Order Relaxation Measurements of Lipid Membranes: Challenges of Jeener-Broekaert Experiments. NMR in Biomed (2025) – under review
11. Kemp-Harper, R., et al. 23Na NMR methods for selective observation of sodium ions in ordered environments. PNAS. (1997): 30(3-4):157-18. Doi:10.1016/S0079-6565(97)00001-0 [doi]
12. Varma, G., et al. In vivo measurement of a new source of contrast, the dipolar relaxation time, T1D, using a modified inhomogeneous magnetization transfer (ihMT) sequence. Magn. Reson. Med. 78.4 (2017): 1362-1372. Doi:10.1002/mrm.26523 [doi]
13. Wilhelm, M. J., et al. Direct magnetic resonance detection of myelin and prospects for quantitative imaging of myelin density. PNAS 109.24 (2012): 9605-9610. Doi:10.1073/pnas.1115107109 [doi]
14. Müller, D. K. et al. Matrix-algebra-based calculations of the time evolution of the binary spin-bath model for magnetization transfer. J. Magn. Reson. (2013): 230: 88–97 Doi:10.1016/j.jmr.2013.01.013 [doi]
15. Wallstein, N., et al. An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter. Sci. Rep. 15.1 (2025): 4354. Doi:10.1038/s41598-025-87362-4 [doi]
16. Wallstein, N. et al. Anisotropic longitudinal water proton relaxation in white matter investigated ex vivo in porcine spinal cord with sample rotation. Sci. Rep. 14, (2024): Doi:10.1038/s41598-024-63483-0 [doi]
17. Fralix, T. A., et al. Lipid bilayer and water proton magnetization transfer: effect of cholesterol. Magn. Reson. Med. 18.1 (1991): 214-223. Doi:10.1002/mrm.1910180122 [doi]
18. Kucharczyk, W., et al. Relaxivity and magnetization transfer of white matter lipids at MR imaging: importance of cerebrosides and pH. Radiology 192.2 (1994): 521-529. Doi:10.1148/radiology.192.2.8029426 [doi]
19. van Gelderen, P., et al. Rapid measurement of brain macromolecular proton fraction with transient saturation transfer MRI. Magn. Reson. Med. 77.6 (2017): 2174-2185 Doi:10.1002/mrm.26304 [doi]

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http://echo.ismrm.org/p/ISMRM2026/301-04-004