Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
366-06-009 ISMRM Abstract

Time-dependent diffusion MRI for early prediction of pCR to neoadjuvant immunotherapy in locally advanced rectal cancer

Primary: Diffusion - Microstructure
Secondary: Body - Pelvis
366-06-009 · Body Diffusion MRI Applications · Monday, 11 May, 5:05 PM–6:00 PM · Digital Posters Row G
Keywords: Time-dependent diffusion MRI Locally advanced rectal cancer Pathological complete response Neoadjuvant immunochemotherapy (NICT)
Accepted
Ziwei Jin 1, Lan Zhang1, Na Hao1, Peng Sun2, Ning Zheng3,4, Xin Li1
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan 430022, Hubei Province, China
2Institute of Research and Clinical Innovations, Neusoft Medical Systems Co. Ltd, Shenyang, China
3Philips Healthcare (Beijing), Beijing, China
4Clinical and Technical Support, Philips Healthcare (Beijing), Beijing, China
Presenting Author: Ziwei Jin

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References

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2. Beer L, Hochmair M, Prosch H. Pitfalls in the radiological response assessment of immunotherapy. Memo. 2018;11(2):138-143. doi: 10.1007/s12254-018-0389-x. [doi]
3. Costa LB, Queiroz MA, Barbosa FG, Nunes RF, Zaniboni EC, Ruiz MM, Jardim D, Gomes Marin JF, Cerri GG, Buchpiguel CA. Reassessing Patterns of Response to Immunotherapy with PET: From Morphology to Metabolism. Radiographics. 2021 Jan-Feb;41(1):120-143. doi: 10.1148/rg.2021200093. [doi]
4. Ge Y, Jia Y, Li X, Dou W, Chen Z, Yan G. T2 relaxation time for the early prediction of treatment response to chemoradiation in locally advanced rectal cancer. Insights Imaging. 2022 Jul 7;13(1):113. doi: 10.1186/s13244-022-01254-z. [doi]
5. Boldrini L, Charles-Davies D, Romano A, Mancino M, Nacci I, Tran HE, Bono F, Boccia E, Gambacorta MA, Chiloiro G. Response prediction for neoadjuvant treatment in locally advanced rectal cancer patients-improvement in decision-making: A systematic review. Eur J Surg Oncol. 2025 Jul;51(7):109463. doi: 10.1016/j.ejso.2024.109463. [doi]
6. Hundvin JA, Habrich J, Gani C, Assmus J, Løes IM, Pilskog S, Redalen KR, Thorwarth D. Early response prediction during radiotherapy in rectal cancer using sequential diffusion-weighted imaging at a magnetic resonance image-guided linear accelerator. Phys Imaging Radiat Oncol. 2025 Oct 8;36:100846. doi: 10.1016/j.phro.2025.100846. [doi]
7. Jiang X, Li H, Devan SP, Gore JC, Xu J. MR cell size imaging with temporal diffusion spectroscopy. Magn Reson Imaging. 2021 Apr;77:109-123. doi: 10.1016/j.mri.2020.12.010. [doi]
8. Xu J. Probing neural tissues at small scales: Recent progress of oscillating gradient spin echo (OGSE) neuroimaging in humans. J Neurosci Methods. 2021 Feb 1;349:109024. doi: 10.1016/j.jneumeth.2020.109024. [doi]

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http://echo.ismrm.org/p/ISMRM2026/366-06-009