Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
366-01-008 ISMRM Abstract

Deep Gray Matter Susceptibility Changes in Cerebral Small Vessel Disease: A 7T QSM Study

Primary: Neuro - Stroke and Cerebrovascular Disorders
Secondary: Contrast Mechanisms - Susceptibility/QSM
366-01-008 · Cerebral Small Vessel Disease: Imaging Biomarkers, Pathophysiology, and Clinical Impact · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row G
Keywords: Cerebral small vessel disease Quantitative Susceptibility Mapping (QSM) Deep gray matter nuclei 7T MRI
Accepted
Yue Yuan1, Shuai Jiang1, Youjie Wang1, Huilou Liang2, Michela Tosetti3, Marta Lancione3, Siyi Li 4, Jiaxin Zeng4, Lu Tang4, Pengfei Peng4, Jiayu Sun4, Su Lui4, Bo Wu1
1Department of Neurology, West China Hospital of Sichuan University, Chengdu, China
2GE HealthCare MR Research, Beijing, China
3IRCCS Fondazione Stella Maris, Pisa, Italy
4West China Hospital of Sichuan University, Chengdu, China
Presenting Author: Siyi Li

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References

1. Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 2013;12(8):822-838. doi:10.1016/S1474-4422(13)70124-8 [doi]
2. Van Den Brink H, Pham S, Siero JC, et al. Assessment of small vessel function using 7T MRI in patients with sporadic cerebral small vessel disease: the ZOOM@SVDs study. Neurology. 2024;102(5):e209136. doi:10.1212/WNL.0000000000209136 [doi]
3. Li J, Nguyen TD, Zhang Q, Guo L, Wang Y. Cerebral microbleeds are associated with increased brain iron and cognitive impairment in patients with cerebral small vessel disease: a quantitative susceptibility mapping study. J Magn Reson Imaging. 2022;56(3):904-914. doi:10.1002/jmri.28092 [doi]
4. Chen L, Soldan A, Faria A, et al. Susceptibility MRI Helps Predict Mild Cognitive Impairment Onset and Cognitive Decline in Cognitively Unimpaired Older Adults. Radiology. 2025;316(3):e250513. doi:10.1148/radiol.250513 [doi]
5. Chen Y, Li M, Li J, et al. Microstructural changes in the caudate nucleus and hippocampus and their association with cognitive function in cerebral small vessel disease: a quantitative susceptibility mapping study. Neurobiol Dis. 2025;212:106964. doi:10.1016/j.nbd.2025.106964 [doi]
6. Tian Y, Margulies DS, Breakspear M, Zalesky A. Topographic organization of the human subcortex unveiled with functional connectivity gradients. Nat Neurosci. 2020;23(11):1421-1432. doi:10.1038/s41593-020-00711-6 [doi]
7. Zhi Y, Huang T, Liu S, et al. Correlation between iron deposition and cognitive function in mild to moderate alzheimer’s disease based on quantitative susceptibility mapping. Front Aging Neurosci. 2024;16:1485530. doi:10.3389/fnagi.2024.1485530 [doi]
8. Ouhaz Z, Fleming H, Mitchell AS. Cognitive functions and neurodevelopmental disorders involving the prefrontal cortex and mediodorsal thalamus. Front Neurosci. 2018;12. doi:10.3389/fnins.2018.00033 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/366-01-008