662-02-008 ISMRM Abstract

Proton exchange rate (kₑₓ) in CEST MRI as a surrogate imaging marker for hydroxyl radicals validated in a small metabolite

Primary: Contrast Mechanisms - CEST / APT / NOE

Secondary: Contrast Mechanisms - Molecular Imaging

662-02-008 · Advances in Chemical Exchange MRI: CEST, APT, and NOE II · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row C

Keywords: Creatine CEST MRI Oxidative stress Exchange Rate Mapping CEST-MRI post-processing

Accepted

Mehran Shaghaghi¹, Kejia Cai ^1,2

¹University of Illinois Chicago, Chicago, United States of America

²University of Illinois at Chicago, Chicago, United States of America

Presenting Author: Kejia Cai

Synopsis

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References

1. Tain RW, Scotti AM, Li W, Zhou XJ, Cai K. Imaging short‐lived reactive oxygen species (ROS) with endogenous contrast MRI. Journal of Magnetic Resonance Imaging. 2018 Jan;47(1):222-9. https://doi.org/10.1002/jmri.25763 [doi]

2. Tain RW, Scotti AM, Cai K. Improving the detection specificity of endogenous MRI for reactive oxygen species (ROS). Journal of Magnetic Resonance Imaging. 2019 Aug;50(2):583-91. https://doi.org/10.1002/jmri.26629 [doi]

3. Zaiss M, Jin T, Kim SG, Gochberg DF. Theory of chemical exchange saturation transfer MRI in the context of different magnetic fields. NMR in Biomedicine. 2022 Nov;35(11):e4789. https://doi.org/10.1002/nbm.4789 [doi]

4. Shaghaghi M, Cai K. Toward in vivo MRI of the tissue proton exchange rate in humans. Biosensors. 2022 Oct 1;12(10):815. https://doi.org/10.3390/bios12100815 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/662-02-008