Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
361-04-006 ISMRM Abstract

Reproducible Detection of the Amine (2.75 ppm) Signal in the Human Brain with CEST Imaging at 5T

Primary: Contrast Mechanisms - CEST / APT / NOE
Secondary: Physics & Engineering - High-Field MRI
361-04-006 · Advanced Neuroimaging with MRI: CEST and APT Techniques · Monday, 11 May, 2:45 PM–3:40 PM · Digital Posters Row B
Keywords: Amide Guanidino Amine Chemical Exchange Saturation Transfer (CEST) MRI Ultra high field
Accepted
qifan pang1,2, Ruibin Liu3, ziqi Yu1,2, ziyi Wang1,2, Shuheng Zhang3, Dengrong Jiang4, Xingfeng Shao2,5, Fuhua Yan1,2, Xiao-Yong Zhang1,2
1Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Shanghai United Imaging Healthcare Co., Ltd, Shanghai, China
4National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
5Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Presenting Author: Jiawen Sun

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References

1. Xu J, Chung JJ, Jin T. Chemical exchange saturation transfer imaging of creatine, phosphocreatine, and protein arginine residue in tissues. NMR Biomed. Jun 2023;36(6):e4671. doi:10.1002/nbm.4671 [doi]
2. Wang K, Ju L, Qiao G, et al. Elucidating metabolite and pH variations in stroke through guanidino, amine and amide CEST MRI: A comparative multi-field study at 9.4T and 3T. Neuroimage. Jan 2025;305:120993. doi:10.1016/j.neuroimage.2024.120993 [doi]
3. Chen L, Zeng H, Xu X, et al. Investigation of the contribution of total creatine to the CEST Z-spectrum of brain using a knockout mouse model. NMR Biomed. 2017;30(12):10.1002/nbm.3834. doi:10.1002/nbm.3834 [doi]
4. Zaiss M, Ehses P, Scheffler K. Snapshot-CEST: Optimizing spiral-centric-reordered gradient echo acquisition for fast and robust 3D CEST MRI at 9.4 T. NMR Biomed. Apr 2018;31(4):e3879. doi:10.1002/nbm.3879 [doi]
5. Kim M, Gillen J, Landman BA, Zhou J, van Zijl PC. Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn Reson Med. Jun 2009;61(6):1441-50. doi:10.1002/mrm.21873 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/361-04-006