Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
352-03-012 / 352-03-012 ISMRM Abstract

Imaging neural activity induced modifications of water exchange using T2-selective saturation labeling

Primary: Neuro - Neurofluids
Secondary: Brain Function and fMRI - fMRI Acquisition
352-03-012 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
352-03-012 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
Keywords: fMRI (task based) Glymphatics Tissue-CSF water exchange
Accepted
Manuel Taso 1, Ruby Bouhassira2, David C Alsop3, John A Detre1,2, Geoffrey K Aguirre2
1Department of Radiology, University of Pennsylvania, Philadelphia, United States of America
2Department of Neurology, University of Pennsylvania, Philadelphia, United States of America
3Beth Israel Deaconess Medical Center, Boston, United States of America
Presenting Author: Manuel Taso

Synopsis

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References

1. Iliff, J. J. et al. A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β. Sci. Transl. Med. 4, 147ra111-147ra111 (2012).
2. Rasmussen, M. K., Mestre, H. & Nedergaard, M. The glymphatic pathway in neurological disorders. Lancet Neurol. 17, 1016–1024 (2018).
3. van Veluw, S. J. et al. Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain. Neuron 105, 549-561.e5 (2020).
4. Hirschler, L. et al. Region-specific drivers of CSF mobility measured with MRI in humans. Nat. Neurosci. 1–10 (2025) doi:10.1038/s41593-025-02073-3. [doi]
5. Taso, M. & Alsop, D. C. Tissue-to-fluid water-exchange imaging using T2-selective saturation labeling. Magn. Reson. Med. 94, 150–165 (2025).
6. Smith, S. M. et al. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23, Supplement 1, S208–S219 (2004).
7. Dale, A. M., Fischl, B. & Sereno, M. I. Cortical Surface-Based Analysis: I. Segmentation and Surface Reconstruction. NeuroImage 9, 179–194 (1999).
8. Alsop, D. C., Jaafar, N. & Taso, M. T2 selective saturation labeling for imaging of water exchange between tissues and CSF. in Proceedings of the annual meeting of the ISMRM 996 (Singapore, 2024).
9. Papadopoulos, M. C. & Verkman, A. S. Aquaporin water channels in the nervous system. Nat. Rev. Neurosci. 14, 265–277 (2013).
10. Wang, Z. et al. The contributions of aquaporin-4 to water exchange across the blood–brain barrier measured by filter-exchange imaging. Magn. Reson. Med. 2025 (in press)
11. Mateo, C., Knutsen, P. M., Tsai, P. S., Shih, A. Y. & Kleinfeld, D. Entrainment of Arteriole Vasomotor Fluctuations by Neural Activity Is a Basis of Blood-Oxygenation-Level-Dependent “Resting-State” Connectivity. Neuron 96, 936-948.e3 (2017).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/352-03-012