Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
271-01-040 / 405-04-002 ISMRM Abstract

Characterization and longitudinal assessment of myocardial microstructure in ICI myocarditis using ultra-high-gradient cDTI

Primary: Diffusion - DWI/DTI/DKI
Secondary: Cardiovascular - Inflammation, Infiltration
271-01-040 · ISMRM AMPC Selected Posters · Sunday, 10 May, 7:00 AM–2:00 PM · Traditional Posters
405-04-002 · From Diffusion Characteristics Toward Clinical Impact · Tuesday, 12 May, 4:00 PM–5:50 PM · Ballroom West
Keywords: Myocarditis Diffusion Tensor Imaging Ultra High Performance Gradients Immune checkpoint inhibitors Cardiac microstructure
Accepted
Xianling Qian1, Ling Chen1, Zhuolin Liu1, Jili Chen1, Christopher Nguyen2, Caixia Fu3, xiaoming Liu4, Yuchi Liu 5, Yishi Wang4, Yunzhu Wu6, Jing An3, Danielle Kara2, Dingheng Mai2, Moses P Cook2, Zachary Player2, Xuhao Song1, Yinyin Chen1, Hang Jin1, Mengsu Zeng1
1Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Cardiovascular Innovation Research Center, Heart Vascular Thoracic Institute, Cleveland Clinic, Cleveland, United States of America
3MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China
4Research Collaboration Team, Siemens Healthineers, Beijing, China
5Cardiovascular MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Cleveland, United States of America
6Research Collaboration Team, Siemens Healthineers, Shanghai, China
Presenting Author: Yuchi Liu

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References

1. Bonaca MP, Olenchock BA, Salem J-E, et al. Myocarditis in the setting of cancer therapeutics: Proposed case definitions for emerging clinical syndromes in cardio-oncology. Circulation. 2019;140(1):80-91.
2. De Perna ML, Rigamonti E, Zannoni R, et al. Immune checkpoint inhibitors and cardiovascular adverse events. ESC Heart Failure. 2025;12(4):2404-2416.
3. Tocchetti CG, Farmakis D, Koop Y, et al. Cardiovascular toxicities of immune therapies for cancer – a scientific statement of the heart failure association ( HFA ) of the ESC and the ESC council of cardio‐oncology. European Journal of Heart Failure. 2024;26(10):2055-2076.
4. Chen Y-C, Dolladille C, Rao A, et al. Immune checkpoint inhibitor myocarditis and left ventricular systolic dysfunction. JACC: CardioOncology. 2025;7(3):234-248.
5. Lehmann LH, Cautela J, Palaskas N, et al. Clinical strategy for the diagnosis and treatment of immune checkpoint inhibitor–associated myocarditis: A narrative review. JAMA Cardiology. 2021;6(11):1329.
6. Zhang L, Awadalla M, Mahmood SS, et al. Cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis. European Heart Journal. 2020;41(18):1733-1743.
7. Doris E, Manisty C, Ramalingam S, et al. Imaging immune checkpoint inhibitor myocarditis. JACC: CardioOncology. 2025:S2666087325002947.
8. Ferreira VM, Schulz-Menger J, Holmvang G, et al. Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation: Expert Recommendations. J Am Coll Cardiol. 2018;72(24):3158-3176.
9. Khalique Z, Ferreira PF, Scott AD, et al. Diffusion Tensor Cardiovascular Magnetic Resonance Imaging: A Clinical Perspective. JACC Cardiovasc Imaging. 2020;13(5):1235-1255.
10. Dall'Armellina E, Ennis DB, Axel L, et al. Cardiac diffusion-weighted and tensor imaging: A consensus statement from the special interest group of the Society for Cardiovascular Magnetic Resonance. J Cardiovasc Magn Reson. 2025;27(1):101109.
11. Nielles-Vallespin S, Khalique Z, Ferreira PF, et al. Assessment of Myocardial Microstructural Dynamics by In Vivo Diffusion Tensor Cardiac Magnetic Resonance. J Am Coll Cardiol. 2017;69(6):661-676.
12. Chowdhary A, Garg P, Das A, et al. Cardiovascular magnetic resonance imaging: emerging techniques and applications. Heart. 2021;107(9):697-704.
13. Messroghli DR, Moon JC, Ferreira VM, et al. Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the society for cardiovascular magnetic resonance (SCMR) endorsed by the european association for cardiovascular imaging (EACVI). Journal of Cardiovascular Magnetic Resonance. 2016;19(1):75.
14. Herrmann J, Lenihan D, Armenian S, et al. Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement. Eur Heart J. 2022;43(4):280-299.
15. Kara D, Liu Y, Chen S, et al. In vivo cardiac diffusion tensor imaging on an MR system featuring ultrahigh performance gradients with 200 mT/m maximum gradient strength. Magn Reson Med. 2025;93(2):673-688.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/271-01-040