370-04-031 ISMRM Abstract

23NaMRI signal separation based on T2 relaxation in patients with Alzheimer’s Disease and matched healthy controls

Primary: Neuro - Alzheimer's Disease

Secondary: Analysis Methods - Data Processing

370-04-031 · Analysis in Neurodegenerative Disease · Monday, 11 May, 1:50 PM–2:45 PM · Traditional Posters | Exhibition Hall

Keywords: Aging Alzheimer's Disease Imaging biomarkers 23Na MRI

Accepted

Sara Hejazi^1,2, Ying-Chia Lin^1,2, Alaleh Alivar^1,2, Kennedy Watson^1,2, Kamri B Clarke^1,2, Justin Quimbo¹, Malika Kumbella¹, Simon Henin³, Yulin Ge^1,2, Arjun Masurkar⁴, Anli Liu³, Fernando E Boada⁵, Yvonne W Lui^1,2, Yongxian Qian ^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, United States of America

²Center for Advanced Imaging Innovation and Research (CAI²R), New York University Grossman School of Medicine, New York, United States of America

³Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine, New York, United States of America

⁴Alzheimer’s Disease Research Center, Department of Neurology, New York University Grossman School of Medicine, New York, United States of America

⁵Department of Radiology, Stanford University, Stanford, United States of America

Presenting Author: Yongxian Qian

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References

1. Ridley B, Morsillo F, Zaaraoui W, Nonino F. Variability by region and method in human brain sodium concentrations estimated by 23Na magnetic resonance imaging: a meta-analysis. Sci Rep. 2023 Feb 24;13(1):3222.

2. Qian Y, Lin YC, Chen X, Ge Y, Lui YW, Boada FE. Single-quantum sodium MRI at 3 T for separation of mono- and bi-T2 sodium signals. Sci Rep. 2025 July 28;15(1):27427.

3. Fischl B. FreeSurfer. NeuroImage. 2012 Aug;62(2):774–81.

4. Qian Y, Panigrahy A, Laymon CM, Lee VK, Drappatz J, Lieberman FS, et al. Short‐T2 imaging for quantifying concentration of sodium (23 Na) of bi‐exponential T2 relaxation. Magn Reson Med. 2015 July;74(1):162–74.

5. Harrington MG, Salomon RM, Pogoda JM, Oborina E, Okey N, Johnson B, et al. Cerebrospinal fluid sodium rhythms. Cerebrospinal Fluid Res. 2010 Dec;7(1):3.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/370-04-031