Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-02-001 ISMRM Abstract

PSMD revealed brain-wide white matter damage was associated with cognitive impairment in patients with narcolepsy type 1

Primary: Neuro - White Matter
Secondary: Diffusion - DWI/DTI/DKI
663-02-001 · Diffusion: DWI/DTI/DKI · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row D
Keywords: White Matter Diffusion Tensor Imaging Cognitive impairment Sleep disorders Narcolepsy
Accepted
Pengxin Hu 1, Jiankun Dai2, Xiaoping Tang1
1The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, China
2MR Research, Beijing, China
Presenting Author: Pengxin Hu

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References

1. [1] Longstreth W T, Jr., Koepsell T D, Ton T G, et al. The epidemiology of narcolepsy [J]. Sleep, 2007, 30(1): 13-26. https://doi.org/10.1002/ana.24758 [doi]
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3. [3] Malter M, Neuneier J, Triller A, et al. [Narcolepsy in adults: Definition, etiology and treatment] [J]. Fortschr Neurol Psychiatr, 2021, 89(3): 103-13. https://doi.org/10.2147/ndt.S174293 [doi]
4. [4] Morse A M. Narcolepsy in Children and Adults: A Guide to Improved Recognition, Diagnosis and Management [J]. Med Sci (Basel), 2019, 7(12). https://doi.org/10.1093/sleep/30.1.13 [doi]
5. [5] Zanon Zotin M C, Yilmaz P, Sveikata L, et al. Peak Width of Skeletonized Mean Diffusivity: A Neuroimaging Marker for White Matter Injury [J]. Radiology, 2023, 306(3): e212780. https://doi.org/10.1055/a-1244-2612 [doi]
6. [6] Baykara E, Gesierich B, Adam R, et al. A Novel Imaging Marker for Small Vessel Disease Based on Skeletonization of White Matter Tracts and Diffusion Histograms [J]. Ann Neurol, 2016, 80(4): 581-92. https://doi.org/10.3390/medsci7120106 [doi]
7. [7] Huang L, Chen K L, Lin B Y, et al. Chinese version of Montreal Cognitive Assessment Basic for discrimination among different severities of Alzheimer's disease [J]. Neuropsychiatr Dis Treat, 2018, 14: 2133-40. https://doi.org/10.1212/wnl.0000000000207854 [doi]
8. [8] Perosa V, Zanon Zotin M C, Schoemaker D, et al. Association Between Hippocampal Volumes and Cognition in Cerebral Amyloid Angiopathy [J]. Neurology, 2024, 102(2): e207854. https://doi.org/10.1177/0271678x241261771 [doi]
9. [9] Rasing I, Vlegels N, Schipper M R, et al. Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy [J]. J Cereb Blood Flow Metab, 2024: 271678x241261771. https://doi.org/10.1148/radiol.212780 [doi]

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http://echo.ismrm.org/p/ISMRM2026/663-02-001