Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
406-02-007 ISMRM Abstract

High-Resolution Intrinsic MRE of the Human Brain on the NexGen7T with an Anisotropic, Viscoelastic Tissue Model

Primary: Contrast Mechanisms - Elastography
Secondary: Neuro - Neurofluids
406-02-007 · The Dynamic Brain: Flow, Pressure, and Exchange · Tuesday, 12 May, 1:40 PM–3:30 PM · Auditorium 2
Keywords: Ultra-high field Glymphatic system Intrinsic MR elastography (iMRE) High spatial resolution
Accepted
Kulam Najmudeen Magdoom1,2,3,4, Oleksandr Khegai5, Erica B Walker5,6, Alexander J Beckett5,6, Alexandru V Avram4, David Feinberg 5,7, An T Vu8,9, Peter J Basser4
1The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, United States of America
2Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, United States of America
3Uniformed Services University of the Health Sciences, Bethesda, United States of America
4Section on Quantitative Imaging and Tissue Sciences (SQITS), Eunice Kennedy Shriver - National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, United States of America
5Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, United States of America
6Advanced MRI Technologies, LLC, Sebastopol, United States of America
7Department of Neuroscience, University of California, Berkeley, United States of America
8Department of Radiology and Biomedical Imaging, University Of California, San Francisco (UCSF), United States of America
9Northern California Institute for Research and Education, San Francisco, United States of America
Presenting Author: David Feinberg

Synopsis

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References

1. Weaver, J. B., Pattison, A. J., McGarry, M. D., Perreard, I. M., Swienckowski, J. G., Eskey, C. J., ... & Paulsen, K. D. (2012). Brain mechanical property measurement using MRE with intrinsic activation. Physics in Medicine & Biology, 57(22), 7275.
2. Johnson, C. L., McGarry, M. D., Van Houten, E. E., Weaver, J. B., Paulsen, K. D., Sutton, B. P., & Georgiadis, J. G. (2013). Magnetic resonance elastography of the brain using multishot spiral readouts with self‐navigated motion correction. Magnetic resonance in medicine, 70(2), 404-412.
3. Feinberg, David A., et al. "Next-generation MRI scanner designed for ultra-high-resolution human brain imaging at 7 Tesla." Nature methods 20.12 (2023): 2048-2057.
4. Magdoom, K. N., Avram, A. V., Sarlls, J. E., & Basser, P. J. (2025). In vivo palpation of anisotropic human brain tissue using MRI. bioRxiv, 2025-06.
5. Basser, Peter J., James Mattiello, and Denis LeBihan. "MR diffusion tensor spectroscopy and imaging." Biophysical journal 66.1 (1994): 259-267.
6. Sinkus, R., et al. "Imaging anisotropic and viscous properties of breast tissue by magnetic resonance‐elastography." Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine 53.2 (2005): 372-387.
7. Cowin, S. C. (1989). Properties of the anisotropic elasticity tensor. The Quarterly Journal of Mechanics and Applied Mathematics, 42(2), 249-266.
8. Feinberg, D. A., & Mark, A. S. (1987). Human brain motion and cerebrospinal fluid circulation demonstrated with MR velocity imaging. Radiology, 163(3), 793-799.
9. Poncelet, B. P., Wedeen, V. J., Weisskoff, R. M., & Cohen, M. S. (1992). Brain parenchyma motion: measurement with cine echo-planar MR imaging. Radiology, 185(3), 645-651.
10. Sloots, J. J., Biessels, G. J., & Zwanenburg, J. J. (2020). Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI. Neuroimage, 210, 116581.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/406-02-007