Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
662-02-006 ISMRM Abstract

Overcoming the Limitations of Multi-Compartment Models: A Single-Compartment Phantom for Brain CEST MRI

Primary: Contrast Mechanisms - CEST / APT / NOE
Secondary: Physics & Engineering - Phantoms
662-02-006 · Advances in Chemical Exchange MRI: CEST, APT, and NOE II · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row C
Keywords: Brain Phantoms CEST MRI
Accepted
Kalle Inget 1,2,3, Noora Paldán4, Minna Mannerkorpi1, Iida Nikkinen4, Sakari S Karhula1,2,3, Santeri Rytky1,3,5, Tuula A Salo3,6,7,8,9, Lasse Pakanen3,4,10, Krista Juurikka4, Pirjo Åström4, Juha Nikkinen1,3,11
1Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland
2Oulu University Hospital, Oulu, Finland
3Medical Research Center, Oulu, Finland
4Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland
5Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
6Research Unit of Population Health, University of Oulu, Oulu, Finland
7Helsinki University Central Hospital, Finland
8Translational Immunology Research Program (TRIMM), University of Helsinki, Helsinki, Finland
9HUSLAB, Department of Pathology, Helsinki University Central Hospital, Finland
10Finnish Institute for Health and Welfare, Oulu, Finland
11Department of Oncology and Radiotherapy, Oulu University Hospital, Oulu, Finland
Presenting Author: Kalle Inget

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References

1. Huang, J., Chen, Z., Park, S. W., Lai, J. H., & Chan, K. W. (2022). Molecular imaging of brain tumors and drug delivery using CEST MRI: promises and challenges. Pharmaceutics, 14(2), 451. https://doi.org/10.3390/pharmaceutics14020451 [doi]
2. Wada, T., Tokunaga, C., Togao, O., Hiwatashi, A., Kikuchi, K., Yoneyama, M., ... & Yabuuchi, H. (2022). Three-dimensional chemical exchange saturation transfer imaging using compressed SENSE for full z-spectrum acquisition. Magnetic Resonance Imaging, 92, 58-66. https://doi.org/10.1016/j.mri.2022.05.014 [doi]
3. Harris, R. J., Cloughesy, T. F., Liau, L. M., Nghiemphu, P. L., Lai, A., Pope, W. B., & Ellingson, B. M. (2016). Simulation, phantom validation, and clinical evaluation of fast pH‐weighted molecular imaging using amine chemical exchange saturation transfer echo planar imaging (CEST‐EPI) in glioma at 3 T. NMR in Biomedicine, 29(11), 1563-1576. https://doi.org/10.1002/nbm.3611 [doi]
4. Oh, J. H., Kim, H. G., Woo, D. C., Jeong, H. K., Lee, S. Y., & Jahng, G. H. (2017). Chemical-exchange-saturation-transfer magnetic resonance imaging to map gamma-aminobutyric acid, glutamate, myoinositol, glycine, and asparagine: phantom experiments. Journal of the Korean Physical Society, 70(5), 545-553. https://doi.org/10.3938/jkps.70.545 [doi]
5. Paldan, Nikkinen, Risteli, Pakanen, Luukkainen, Kuusisto, Kuittinen, Palosaari, Lehenkari, Räsänen, Huhta, Koivunen, Salo, Juurikka, and Åström. Novel brain-derived gel for in vitro modeling. 21st Science Day of the Kontinkangas Campus: Infrastructure enabling science, 2024.
6. Kleinman, H. K., & Martin, G. R. (2005, October). Matrigel: basement membrane matrix with biological activity. In Seminars in cancer biology (Vol. 15, No. 5, pp. 378-386). Academic Press. https://doi.org/10.1016/j.semcancer.2005.05.004 [doi]

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http://echo.ismrm.org/p/ISMRM2026/662-02-006