Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
601-03-006 / 271-01-054 ISMRM Abstract

A High-Resolution Deuterium Metabolic Imaging and Unsupervised Clustering Framework for Unraveling Intratumoral Heterogeneity

Primary: Contrast Mechanisms - Deuterium
Secondary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
601-03-006 · Spectroscopy and Spectroscopic Imaging · Thursday, 14 May, 4:00 PM–5:50 PM · Hall 1A
271-01-054 · ISMRM AMPC Selected Posters · Sunday, 10 May, 7:00 AM–2:00 PM · Traditional Posters
Keywords: Deuterium Metabolic Imaging Clustering analysis Intratumoral heterogeneity Balanced steady-state free precession (bSSFP) Fast MRSI
Accepted
Xinjie Liu 1,2, Shasha Wang1, Elton T Montrazi3,4,5, Lucio Frydman6, Xin Zhou1,7,8,9,10,11,12,13,14, Maili Liu1,2,7,9, Chaoyang Liu1,2,7, Qingjia Bao1,2,7,9
1Innovation Academy for Precision Measurement Science and Technology,CAS, Wuhan, China
2State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, China
3Weizmann Institute, Rehovot, Israel
4Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, Israel
5Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel
6Weismann Institute, Israel
7University of Chinese Academy of Sciences, Beijing, China
8Hainan University, Sanya, China
9State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China
10State Key Laboratory of Digital Medical Engineering, Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Sanya, China
11School of Biomedical Engineering, Hainan University, Haikou, China
12School of Biomedical Engineering, Guangzhou, China
13State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences - Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, China
14Huazhong University of Science and Technology, Wuhan, China
Presenting Author: Xinjie Liu

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References

1. Demicco M, Liu X-Z, Leithner K, et al. Metabolic heterogeneity in cancer. Nature Metabolism, 2024, 6(1): 18-38.
2. Kim J, Deberardinis R J. Mechanisms and Implications of Metabolic Heterogeneity in Cancer. Cell Metabolism, 2019, 30(3): 434-446.
3. De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, et al. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Science advances. 2018;4(8):eaat7314.
4. Liu X, Bao Q, Liu Z, Wang J, Otikovs M, Zhang Z, et al. Exploring Metabolic Aberrations after Intracerebral Hemorrhage In Vivo with Deuterium Metabolic Spectroscopy Imaging. Analytical Chemistry. 2024;96(39):15563-15571.
5. Pan F, Liu X, Wan J, et al. Advances and prospects in deuterium metabolic imaging (DMI): a systematic review of in vivo studies. European Radiology Experimental, 2024, 8(1): 65.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/601-03-006