Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
563-05-016 ISMRM Abstract

Abnormal Resting-State Functional Connectivity of Pain Processing Brain Regions in Sickle Cell Anaemia

Primary: Brain Function and fMRI - Functional Connectivity
Secondary: Neuro - Other Neurodegeneration
563-05-016 · fMRI: Task-Based and Stimulation · Wednesday, 13 May, 4:00 PM–4:55 PM · Digital Posters Row D
Keywords: Genetic Diseases Functional Connectivity Resting-state fMRI Pain Sickle Cell Disease
Accepted
Mitchel Lee 1, Fenella Kirkham2, Karin Shmueli1
1Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom
2UCL Great Ormond Street Institute of Child Health, London, United Kingdom
Presenting Author: Mitchel Lee

Synopsis

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References

1. Kato, G. J. et al. Sickle cell disease. Nat Rev Dis Primers 4, 18010 (2018).
2. Ballas, S. K. & Darbari, D. S. Review/overview of pain in sickle cell disease. Complement Ther Med. 49, 102327 (2020)
3. Nijs, J. et al. Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine. Review Lancet Rheumatol 3, 383–92 (2021).
4. Stotesbury, H., Kawadler, J. M., Saunders, D. E. & Kirkham, F. J. MRI detection of brain abnormality in sickle cell disease. Expert Review of Hematology vol. 14 473–491 (2021).
5. Zempsky, W. T., Stevens, M. C., Santanelli, J. P., Gaynor, A. M. & Khadka, S. Altered Functional Connectivity in Sickle Cell Disease Exists at Rest and during Acute Pain Challenge. Clinical Journal of Pain 33, 1060–1070 (2017).
6. Darbari, D. S. et al. Frequency of Hospitalizations for Pain and Association with Altered Brain Network Connectivity in Sickle Cell Disease. Journal of Pain 16, 1077–1086 (2015).
7. Martucci, K. T. & Mackey, S. C. Neuroimaging of Pain: Human Evidence and Clinical Relevance of Central Nervous System Processes and Modulation. Anesthesiology 128, 1241–1254 (2018).
8. Howard, J. et al. Overnight auto-adjusting continuous airway pressure + standard care compared with standard care alone in the prevention of morbidity in sickle cell disease phase II (POMS2b): study protocol for a randomised controlled trial. Trials 19, 55 (2018).
9. Whitfield-Gabrieli, S. & Nieto-Castanon, A. Conn : A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks. Brain Connectivity 2, 125–141 (2012).
10. Desikan, R. S. et al. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage 31, 968–980 (2006).
11. Tzourio-Mazoyer, N. et al. Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain. NeuroImage 15, 273–289 (2002).
12. Benarroch, E. E. Periaqueductal gray. Neurology 78, 210–217 (2012).
13. Coulombe, M., Erpelding, N., Kucyi, A. & Davis, K. D. Intrinsic functional connectivity of periaqueductal gray subregions in humans. Hum Brain Mapp 37, 1514–1530 (2016).
14. Brett, M., Penny, W. & Kiebel, S. Introduction to random field theory. Human brain function 2, 867–879 (2003).
15. Lee, M., Kirkham, F. & Shmueli, K. Increases in Resting State Network Connectivity in Sickle Cell Anaemia with Spatially Constrained Independent Component Analysis. in International Society for Magnetic Resonance in Medicine 2859 (2025).
16. Hohenschurz-Schmidt, D. J. et al. Linking Pain Sensation to the Autonomic Nervous System: The Role of the Anterior Cingulate and Periaqueductal Gray Resting-State Networks. Front. Neurosci. 14, (2020).
17. Craig, A. D. How do you feel — now? The anterior insula and human awareness. Nat Rev Neurosci 10, 59–70 (2009).
18. Labrakakis, C. The Role of the Insular Cortex in Pain. International Journal of Molecular Sciences 24, 5736 (2023).
19. Beadle, J. N., Tranel, D., Cohen, N. J. & Duff, M. Empathy in Hippocampal Amnesia. Front. Psychol. 4, (2013).
20. Cashdollar, N., Duncan, J. S. & Duzel, E. Challenging the Classical Distinction Between Long-Term and Short-Term Memory: Reconsidering the Role of the Hippocampus. Future Neurology 6, 351–362 (2011).
21. Falconi-Sobrinho, L. L. et al. Activation of NMDA Receptors in the Anterior Cingulate Cortex Enhances Anxiety-Induced Behaviour and Antinociception, and Contributes to the Modulation of Pain-Facilitatory Descending Pathways. European Journal of Pain 29, e70055 (2025).
22. Xiao, X. & Zhang, Y.-Q. A new perspective on the anterior cingulate cortex and affective pain. Neuroscience & Biobehavioral Reviews 90, 200–211 (2018).
23. Kohoutová, L. et al. Individual variability in brain representations of pain. Nat Neurosci 25, 749–759 (2022).
24. Zhang, L.-B. et al. Advances and challenges in neuroimaging-based pain biomarkers. CR Med 5, (2024).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/563-05-016