Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
507-03-005 ISMRM Abstract

Spectral-Spatial Deep Learning for Quantitative gagCEST Mapping of Lumbar Intervertebral Discs

Primary: Acquisition & Reconstruction - AI methods
Secondary: Contrast Mechanisms - CEST / APT / NOE
507-03-005 · New Frontiers in CEST MRI · Wednesday, 13 May, 1:40 PM–3:30 PM · Meeting Room 1.40
Keywords: Simulations CEST / APT / NOE Quantitative Imaging Deep learning 3.0T
Accepted
Mohamed Ali Goundi 1, Karl Ludger Radke1, Matthias Georg Deitermann1, Timm Joachim Filler2, Hans-Joerg Wittsack1, Daniel Benjamin Abrar1, Gerald Antoch1, Anja Müller-Lutz1
1Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich Heine University Düsseldorf (DE), Düsseldorf, Germany
2Center for Anatomy and Brain Research, Medical Faculty, Heinrich Heine University Düsseldorf (DE), Germany
Presenting Author: Mohamed Ali Goundi

Synopsis

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References

1. Müller-Lutz A, Schleich C, Pentang G, Schmitt B, Lanzman RS, Matuschke F, Wittsack HJ, Miese F. Age-dependency of glycosaminoglycan content in lumbar discs: A 3t gagcEST study. J Magn Reson Imaging. 2015 Dec;42(6):1517-23. doi: 10.1002/jmri.24945. Epub 2015 May 12. PMID: 25970563. [doi] [pmid]
2. Schleich C, Müller-Lutz A, Eichner M, Schmitt B, Matuschke F, Bittersohl B, Zilkens C, Wittsack HJ, Antoch G, Miese F. Glycosaminoglycan Chemical Exchange Saturation Transfer of Lumbar Intervertebral Discs in Healthy Volunteers. Spine (Phila Pa 1976). 2016 Jan;41(2):146-52. doi: 10.1097/BRS.0000000000001144. PMID: 26583472. [doi] [pmid]
3. Radke KL, Wilms LM, Frenken M, Stabinska J, Knet M, Kamp B, Thiel TA, Filler TJ, Nebelung S, Antoch G, Abrar DB, Wittsack HJ, Müller-Lutz A. Lorentzian-Corrected Apparent Exchange-Dependent Relaxation (LAREX) Ω-Plot Analysis-An Adaptation for qCEST in a Multi-Pool System: Comprehensive In Silico, In Situ, and In Vivo Studies. Int J Mol Sci. 2022 Jun 22;23(13):6920. doi: 10.3390/ijms23136920. PMID: 35805925; PMCID: PMC9266897. [doi] [pmid]
4. Zaiss M, Bachert P. Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods. Phys Med Biol. 2013 Nov 21;58(22):R221-69. doi: 10.1088/0031-9155/58/22/R221. PMID: 24201125. [doi] [pmid]
5. Sun PZ, Wang Y, Dai Z, Xiao G, Wu R. Quantitative chemical exchange saturation transfer (qCEST) MRI--RF spillover effect-corrected omega plot for simultaneous determination of labile proton fraction ratio and exchange rate. Contrast Media Mol Imaging. 2014 Jul-Aug;9(4):268-75. doi: 10.1002/cmmi.1569. PMID: 24706610; PMCID: PMC4003506. [doi] [pmid]
6. Liebeskind A, Schüre JR, Fabian MS, Weinmüller S, Schünke P, Golkov V, Cremers D, Zaiss M. The Pulseq-CEST Library: definition of preparations and simulations, example data, and example evaluations. MAGMA. 2025 Jul;38(3):413-422. doi: 10.1007/s10334-025-01242-6. Epub 2025 Mar 27. PMID: 40146474; PMCID: PMC12255581. [doi] [pmid]
7. Schuenke, P., Herz, K., Zu, Z., Yadav, N., Zheng, Q., Huemer, M., et al. (2023). Validate your CEST simulation! In 2023 ISMRM & ISMRT Annual Meeting & Exhibition (ISMRM 2023).
8. Stefanou DE, Velonakis G, Karavasilis E, Argyropoulos G, Kelekis A, Kelekis N, Filippiadis D. T2 mapping of lumbar intervertebral disc: quantitative evaluation of degeneration in relation to Pfirrmann grading system and a template for intervertebral disc segmentation. Hippokratia. 2023 Jul-Sep;27(3):75-81. PMID: 39119364; PMCID: PMC11305159. [pmid]
9. Koy T, Zange J, Rittweger J, Pohle-Fröhlich R, Hackenbroch M, Eysel P, Ganse B. Assessment of lumbar intervertebral disc glycosaminoglycan content by gadolinium-enhanced MRI before and after 21-days of head-down-tilt bedrest. PLoS One. 2014 Nov 7;9(11):e112104. doi: 10.1371/journal.pone.0112104. PMID: 25380233; PMCID: PMC4224407. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/507-03-005