Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
566-04-003 ISMRM Abstract

Intravenous Iron Supplementation During Pregnancy: Effects on Fetal Brain Development Assessed by Structural MRI

Primary: Pediatrics - Fetal
Secondary: Pediatrics - Neuro
566-04-003 · Predicting Neurologic Outcomes · Wednesday, 13 May, 2:35 PM–3:30 PM · Digital Posters Row G
Keywords: Brain Development Fetal MRI Structural MRI Iron supplementation
Accepted
Douglas C Dean 1,2,3, Virupaxi Hattiholi4, Mahesh Kamate5, Moriah E Thomason6,7, Kiran S Talekar8, Anmol Patted9, Simal Thind9, Jesse Bradford-Rogers9, Danielle M DeSantis9, Umesh Charantimath10, Manjunath Somannavar11, S Yogeshkumar10, Rebecca Hartman12, Benjamin Leiby12, Roopa Bellad13, Zubair Aghai14, Michael Georgieff15,16,17,18, Shivaprasad Goudar19, Mrutyunjaya Bellad20, Richard Derman9
1Department of Medical Physics, University of Wisconsin - Madison, Madison, United States of America
2Department of Pediatrics, University of Wisconsin - Madison, Madison, United States of America
3University of Wisconsin - Madison, Madison, United States of America
4Department of Radiology, KAHER's J N Medical College, Belgaum, India
5Department of Pediatric Neurology, KAHER's J N Medical College, Belgaum, India
6New York University Langone Health, New York, United States of America
7Department of Population Health, New York University Langone Health, New York, United States of America
8Radiology, Thomas Jefferson University, Philadelphia, United States of America
9Department of Global Affairs, Thomas Jefferson University, Philadelphia, United States of America
10Department of Community Medicine, KAHER's J N Medical College, Belgaum, India
11Department of Biochemistry, KAHER's J N Medical College, Belgaum, India
12Department of Biostatistics and Bioinformatics, Thomas Jefferson University, Philadelphia, United States of America
13Department of Paediatrics, KAHER's J N Medical College, Belgaum, India
14Department of Pediatrics, Thomas Jefferson University, Philadelphia, United States of America
15Department of Pediatrics, University of Minnesota, Minneapolis, United States of America
16Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, United States of America
17Institute of Child Development, University of Minnesota, Minneapolis, United States of America
18Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, United States of America
19Department of Physiology, KAHER's J N Medical College, Belgaum, India
20Department of Obstetrics & Gynecology, KAHER's J N Medical College, Belgaum, India
Presenting Author: Douglas C Dean

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Johnson-Wimbley, T. D. & Graham, D. Y. Diagnosis and management of iron deficiency anemia in the 21st century. Therapeutic advances in Gastroenterology 4, 177–184 (2011).
2. Ben-Ami, T., Natour, M. Q., Rekhtman, D., Ariel, T. & Revel-Vilk, S. Iron Deficiency Anemia As a Leading Cause of Severe Anemia in Children May be Associated with Unnecessary Red Blood Cells (RBCs) Transfusion. Blood 126, 4454–4454 (2015).
3. Omotayo, M. O., Abioye, A. I., Kuyebi, M. & Eke, A. C. Prenatal anemia and postpartum hemorrhage risk: A systematic review and meta-analysis. J Obstet Gynaecol Res 47, 2565–2576 (2021). https://doi.org/10.1111/jog.14834 [doi]
4. Haider, B. A. et al. Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. Bmj 346, f3443 (2013). https://doi.org/10.1136/bmj.f3443 [doi]
5. Radlowski, E. C. & Johnson, R. W. Perinatal iron deficiency and neurocognitive development. Front Hum Neurosci 7, 585 (2013). https://doi.org/10.3389/fnhum.2013.00585 [doi]
6. Congdon, E. L. et al. Iron deficiency in infancy is associated with altered neural correlates of recognition memory at 10 years. J Pediatr 160, 1027–1033 (2012). https://doi.org/10.1016/j.jpeds.2011.12.011 [doi]
7. Lozoff, B. et al. Dose-response relationships between iron deficiency with or without anemia and infant social-emotional behavior. J Pediatr 152, 696–702, 702.631–693 (2008). https://doi.org/10.1016/j.jpeds.2007.09.048 [doi]
8. Georgieff, M. K. The role of iron in neurodevelopment: fetal iron deficiency and the developing hippocampus. Biochem Soc Trans 36, 1267–1271 (2008). https://doi.org/10.1042/BST0361267 [doi]
9. Beard, J. L. & Connor, J. R. Iron status and neural functioning. Annu Rev Nutr 23, 41–58 (2003). https://doi.org/10.1146/annurev.nutr.23.020102.075739 [doi]
10. Beard, J. Iron deficiency alters brain development and functioning. J Nutr 133, 1468s–1472s (2003). https://doi.org/10.1093/jn/133.5.1468S [doi]
11. Dean, D. et al. Neuroimaging Ancillary Study of the IV Iron RAPIDIRON/RAPIDIRON KIDS Trial. VeriXiv 2, 38 (2025).
12. Derman, R. J. et al. RAPIDIRON: Reducing Anaemia in Pregnancy in India-a 3-arm, randomized-controlled trial comparing the effectiveness of oral iron with single-dose intravenous iron in the treatment of iron deficiency anaemia in pregnant women and reducing low birth weight deliveries. Trials 22, 649 (2021). https://doi.org/10.1186/s13063-021-05549-2 [doi]
13. Derman, R. J. et al. RAPIDIRON Trial follow-up study - the RAPIDIRON-KIDS Study: protocol of a prospective observational follow-up study. Trials 24, 818 (2023). https://doi.org/10.1186/s13063-023-07740-z [doi]
14. Uus, A. et al. Deformable Slice-to-Volume Registration for Motion Correction of Fetal Body and Placenta MRI. IEEE Trans Med Imaging 39, 2750–2759 (2020). https://doi.org/10.1109/tmi.2020.2974844 [doi]
15. Uus, A. U. et al. BOUNTI: Brain vOlumetry and aUtomated parcellatioN for 3D feTal MRI. bioRxiv (2023). https://doi.org/10.1101/2023.04.18.537347 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/566-04-003