666-01-002 ISMRM Abstract

Comparing an iterative least squares frequency decomposition method for non-invasive 3D pH imaging against 13C MRSI in vivo

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)

Secondary: Contrast Mechanisms - Molecular Imaging

666-01-002 · Hyperpolarization: Novel Methods · Thursday, 14 May, 8:30 AM–9:25 AM · Digital Posters Row G

Keywords: Hyperpolarized 13C NMR 3D pH-acquisition Z-OMPD Frequency determination Kidney pH

Accepted

Jakob Gaubatz ¹, Florian M Gaksch¹, Sandra Sühnel¹, Oscar P Georgiev¹, Luca Nagel¹, Martin Grashei¹, Franz Schilling^1,2,3

¹Department of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

²Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany

³German Cancer Consortium (DKTK) partner site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany

Presenting Author: Jakob Gaubatz

Synopsis

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References

1. Briguori C, Roscigno G. Low urine pH: a new marker for contrast-associated acute kidney injury? EuroIntervention. 2022;18(7):527-528. doi: 10.4244/EIJ-E-22-00026 [doi]

2. Huber V, Camisaschi C, Berzi A, et al. Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation. Semin Cancer Biol. 2017;43:74-89. doi: 10.1016/j.semcancer.2017.03.001. [doi]

3. Gaubatz J, Wendlinger A, Setzer N et al. Measuring extracellular pH in 3D using an iterative least squares frequency decomposition and hyperpolarized 13C-labelled Z-OMPD. ISMRM 2025; Submission 0298

4. Grashei M, Wodtke P, Skinner JG, et al. Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13C-labelled Z-OMPD. Nat Commun. 2023;14(1):5060. https://doi.org/10.1038/s41467-023-40747-3 [doi]

5. Yu H, McKenzie C, Shimakawa A, et al. Multiecho Reconstruction for Simultaneous Water-Fat Decomposition and T2* Estimation. J Magn Reson Imaging. 2007;26(4):1153-61. doi: 10.1002/jmri.21090. [doi]

6. Branch M, Coleman T, li Y. A Subspace, Interior, and Conjugate Gradient Method for Large-Scale Bound-Constrained Minimization Problems. SIAM Journal on Scientific Computing. 2006. https://doi.org/10.1137/S1064827595289108 [doi]

7. Po H.N, Senozan N.M. The Henderson-Hasselbalch Equation: Its History and Limitations. Journal of Chemical Education. 2001; 78.11:1499. DOI: 10.1021/ed078p1499 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/666-01-002