Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
551-03-011 / 551-03-011 ISMRM Abstract

Lower brain copper levels in the older adult are linked to lower gray matter volume and higher white matter hyperintensities

Primary: Neuro - Aging
Secondary: Neuro - Dementia
551-03-011 · Advanced MRI Biomarkers of Brain Aging, Vascular Health, and Alzheimer’s Disease · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 1
551-03-011 · Advanced MRI Biomarkers of Brain Aging, Vascular Health, and Alzheimer’s Disease · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 1
Keywords: Ex-Vivo Applications Aging White Matter Hyperintensities Histopathology Brain gray matter volumes
Accepted
Md Tahmid Yasar1, Arnold M Evia2, Puja Puja Agarwal2, Sonal Agrawal2, David A Bennett2, Julie A Schneider2, Konstantinos Arfanakis 1,2
1Biomedical Engineering, Illinois Institute of Technology, Chicago, United States of America
2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, United States of America
Presenting Author: Konstantinos Arfanakis

Synopsis

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References

1. 1. An Y, Li S, Huang X, Chen X, et al. The Role of Copper Homeostasis in Brain Disease. Int J Mol Sci. 2022;23(22):13850. doi:10.3390/ijms232213850 [doi]
2. 2. Lutsenko S, Bhattacharjee A, Hubbard AL. Copper handling machinery of the brain. Metallomics. 2010;2(9):596-608. doi:10.1039/c0mt00006j [doi]
3. 3. Agarwal P, Ayton S, Agrawal S, et al. Brain copper may protect from cognitive decline and Alzheimer’s disease pathology: a community-based study. Mol Psychiatry. 2022;27(10):4307-4313. doi:10.1038/s41380-022-01802-5 [doi]
4. 4. Schrag M, Mueller C, Oyoyo U, et al. Iron, zinc and copper in the Alzheimer’s disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion. Prog Neurobiol. 2011;94(3):296-306. doi:10.1016/j.pneurobio.2011.05.001 [doi]
5. 5. Schrag M, Crofton A, Zabel M, et al. Effect of cerebral amyloid angiopathy on brain iron, copper, and zinc in Alzheimer’s disease. J Alzheimers Dis. 2011;24(1):137-149. doi:10.3233/JAD-2010-101503 [doi]
6. 6. Bennett DA, Buchman AS, Boyle PA, et al. Religious Orders Study and Rush Memory and Aging Project. J Alzheimers Dis. 2018;64(s1):S161-S189. doi:10.3233/JAD-179939 [doi]
7. 7. Dawe RJ, Bennett DA, Schneider JA, et al. Ex vivo T2 relaxation: Associations with age-related neuropathology and cognition. Neurobiol Aging. 2014;35(7):1549-1561. doi:10.1016/j.neurobiolaging.2014.01.144 [doi]
8. 8. Yasar MT, Evia AM, Tazwar M, et al. Cerebral Amyloid Angiopathy Is Associated With Higher R2 Relaxation Rate: An MRI and Pathology Study. Ann Clin Transl Neurol. 2025;12(6):1214-1224. doi:10.1002/acn3.70037 [doi]
9. 9. Arfanakis K, Evia AM, Leurgans SE, et al. Neuropathologic Correlates of White Matter Hyperintensities in a Community-Based Cohort of Older Adults. J Alzheimers Dis. 2020;73(1):333-345. doi:10.3233/JAD-190687 [doi]
10. 10. Belaidi AA, Masaldan S, Southon A, et al. Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy. Mol Psychiatry. 2024;29(2):211-220. doi:10.1038/s41380-022-01568-w [doi]
11. 11. Winkler AM, Ridgway GR, Webster MA, et al. Permutation inference for the general linear model. Neuroimage. 2014;92(100):381-397. doi:10.1016/j.neuroimage.2014.01.060 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/551-03-011