Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
665-02-006 Registered Abstract

Investigating structure–function coupling in epilepsy patients undergoing RFTC with graph signal processing

Primary: Neuro - Epilepsy
Secondary: Brain Function and fMRI - fMRI Analysis
665-02-006 · fMRI: Applications in Neurology and Psychiatry II · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row F
Keywords: Epilepsy fMRI Analysis Diffusion Tensor Imaging Structure-function coupling
Accepted
Justyna N Gula 1,2,3, Subhasiny Sankar1, Olaf Schijns1,2,4, Raf van Hoof2, Ilse van Straaten1,2,4,5, Erik Gommer1,6, Borbála Hunyadi4,7,8, Jacobus F Jansen1,3,5, Simon Tousseyn1,2,4
1Mental Health and Neuroscience Research Institute (MHeNs), Maastricht University, Maastricht, Netherlands
2Academic Center for Epileptology (ACE), Kempenhaeghe/Maastricht UMC+, Maastricht and Heeze, Netherlands
3Department of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), Maastricht, Netherlands
4Department of Neurosurgery, Maastricht University Medical Center (MUMC+), Maastricht, Netherlands
5Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
6Department of Clinical Neurophysiology, Maastricht University Medical Center (MUMC+), Maastricht, Netherlands
7Department of Microelectronics, TU Delft, Delft, Netherlands
8Maastricht University, Maastricht, Netherlands
Presenting Author: Justyna N Gula

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References

1. Krishnan B, Tousseyn S, Nayak CS, et al. Neurovascular networks in epilepsy: Correlating ictal blood perfusion with intracranial electrophysiology. Neuroimage. 2021;231:117838. doi:10.1016/j.neuroimage.2021.117838 [doi]
2. Tousseyn S, Dupont P, Goffin K, Sunaert S, Van Paesschen W. Correspondence between large‐scale ictal and interictal epileptic networks revealed by single photon emission computed tomography (SPECT) and electroencephalography (EEG)–functional magnetic resonance imaging (fMRI). Epilepsia. 2015;56(3):382-392. doi:10.1111/epi.12910 [doi]
3. Wilson W, Tehrani N, Pittman DJ, et al. Mapping interictal discharges using intracranial EEG-fMRI to predict postsurgical outcomes. Brain. 2024;147(12):4157-4168. doi:10.1093/brain/awae148 [doi]
4. Chang AJ, Roth RW, Gong R, et al. Network coupling and surgical treatment response in temporal lobe epilepsy: A proof-of-concept study. Epilepsy & Behavior. 2023;149:109503. doi:10.1016/j.yebeh.2023.109503 [doi]
5. Sinha N, Duncan JS, Diehl B, et al. Intracranial EEG Structure-Function Coupling and Seizure Outcomes After Epilepsy Surgery. Neurology. 2023;101(13). doi:10.1212/WNL.0000000000207661 [doi]
6. Preti MG, Van De Ville D. Decoupling of brain function from structure reveals regional behavioral specialization in humans. Nat Commun. 2019;10(1):4747. doi:10.1038/s41467-019-12765-7 [doi]
7. Rigoni I, Rué Queralt J, Glomb K, et al. Structure-function coupling increases during interictal spikes in temporal lobe epilepsy: A graph signal processing study. Clinical Neurophysiology. 2023;153:1-10. doi:10.1016/j.clinph.2023.05.012 [doi]
8. Gula J, Slegers RJ, Van Hoof RHM, et al. The impact of radiofrequency thermocoagulation on brain connectivity in drug‐resistant epilepsy: Insights from stereo‐electroencephalography and cortico‐cortical evoked potentials. Epilepsia. Published online January 20, 2025. doi:10.1111/epi.18270 [doi]
9. Dimova P, de Palma L, Job‐Chapron A, Minotti L, Hoffmann D, Kahane P. Radiofrequency thermocoagulation of the seizure‐onset zone during stereoelectroencephalography. Epilepsia. 2017;58(3):381-392. doi:10.1111/epi.13663 [doi]
10. Scholly J, Pizzo F, Timofeev A, et al. High-frequency oscillations and spikes running down after SEEG-guided thermocoagulations in the epileptogenic network of periventricular nodular heterotopia. Epilepsy Res. 2019;150:27-31. doi:10.1016/j.eplepsyres.2018.12.006 [doi]
11. Russo S, Pigorini A, Mikulan E, et al. Focal lesions induce large-scale percolation of sleep-like intracerebral activity in awake humans. Neuroimage. 2021;234:117964. doi:10.1016/j.neuroimage.2021.117964 [doi]
12. DuPre E, Salo T, Ahmed Z, et al. TE-dependent analysis of multi-echo fMRI with tedana. J Open Source Softw. 2021;6(66):3669. doi:10.21105/joss.03669 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/665-02-006