Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
461-06-002 ISMRM Abstract

Functional MRI compatible simultaneous cortical wide-field fluorescent Ca2+ and intrinsic oxy/deoxy-hemoglobin imaging

Primary: Brain Function and fMRI - fMRI Acquisition
Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods
461-06-002 · Multimodal Acquisitions for Brain Function Studies · Tuesday, 12 May, 4:55 PM–5:50 PM · Digital Posters Row B
Keywords: Hemodynamic Blood Oxygen Level Dependent (BOLD) fMRI Multi-modal imaging Calcium wide-field imaging Brain-imaging
Accepted
Taekyung Kang 1, Francesca Mandino2,3, Nicole Allen1, Omer Mano4, Paul Shamble4, Joel Greenwood4, Evelyn Lake1,2,3
1Yale University, New Haven, United States of America
2Yale School of Medicine, Department of Radiology & Biomedical Imaging, New Haven, United States of America
3Biomedical Imaging Institute, Yale University, New Haven, United States of America
4Neurotechnology Core, Yale University, New Haven, United States of America
Presenting Author: Taekyung Kang

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Lake EMR, Ge X, Shen X, et al. Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI. Nat Methods. 2020;17(12):1262-1271. doi:10.1038/s41592-020-00984-6 [doi]
2. Vafaii H, Mandino F, Desrosiers-Grégoire G, et al. Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization. Nat Commun. 2024;15(1):229. doi:10.1038/s41467-023-44363-z [doi]
3. Mandino F, Horien C, Shen X, et al. Multimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI. Commun Biol. 2025;8(1):665. doi:10.1038/s42003-025-08037-4 [doi]
4. Ma Y, Shaik MA, Kim SH, et al. Wide-field optical mapping of neural activity and brain haemodynamics: considerations and novel approaches. Philos Trans R Soc B Biol Sci. Published online October 5, 2016. doi:10.1098/rstb.2015.0360 [doi]
5. Shahsavarani S, Thibodeaux DN, Xu W, et al. Cortex-wide neural dynamics predict behavioral states and provide a neural basis for resting-state dynamic functional connectivity. Cell Rep. 2023;42(6). doi:10.1016/j.celrep.2023.112527 [doi]
6. Hamodi AS, Martinez Sabino A, Fitzgerald ND, Moschou D, Crair MC. Transverse sinus injections drive robust whole-brain expression of transgenes. eLife. 9:e53639. doi:10.7554/eLife.53639 [doi]
7. Mandino F, Kang T, Shen X, et al. Longitudinal, simultaneous wide-field fluorescent Ca2+ imaging and fMRI in awake mice. bioRxiv. Preprint posted online October 28, 2025:2025.10.27.684863. doi:10.1101/2025.10.27.684863 [doi]
8. Desrosiers-Grégoire G, Devenyi GA, Grandjean J, Chakravarty MM. A standardized image processing and data quality platform for rodent fMRI. Nat Commun. 2024;15(1):6708. doi:10.1038/s41467-024-50826-8 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/461-06-002