Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
361-04-014 ISMRM Abstract

GluCEST MRI Monitors Regional Cerebral Glutamate Dynamics Under Variable Brain Activity

Primary: Neuro - Neurotransmission
Secondary: Preclinical Animal & in vitro MR - Biomarkers
361-04-014 · Advanced Neuroimaging with MRI: CEST and APT Techniques · Monday, 11 May, 2:45 PM–3:40 PM · Digital Posters Row B
Keywords: MRI GluCEST Glutamate 1H MRS Isoflurane
Accepted
Narayan Datt Soni1, Sunil K Khokhar1, Anshuman Swain1, Halvor Juul1, Abeer Mathur1, Dipak Roy1, Blake A Benyard1, Paul S Jacobs1, neil wilson1, Dushyant Kumar1, RAVI PRAKASH REDDY NANGA1, Mohammad Haris1, Ravinder Reddy1
1Department of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine (CAMIPM), University of Pennsylvania, Philadelphia, United States of America
Presenting Author: Ari Borthakur

Synopsis

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References

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2. Lewerenz, J., & Maher, P. (2015). Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?. Frontiers in neuroscience, 9, 469.
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10. Swain, A., Soni, N. D., Wilson, N., Juul, H., Benyard, B., Haris, M., Kumar, D., Nanga, R. P. R., Detre, J., Lee, V. M., & Reddy, R. (2023). Early-stage mapping of macromolecular content in APPNL-F mouse model of Alzheimer's disease using nuclear Overhauser effect MRI. Frontiers in aging neuroscience, 15, 1266859.
11. Provencher S. W. (1993). Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magnetic resonance in medicine, 30(6), 672–679.
12. Larsen, M., Hegstad, E., Berg-Johnsen, J., & Langmoen, I. A. (1997). Isoflurane increases the uptake of glutamate in synaptosomes from rat cerebral cortex. British journal of anaesthesia, 78(1), 55–59.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/361-04-014