Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
666-01-011 ISMRM Abstract

A Dual Multiband RF Pulse Strategy for 3D Volumetric Assessment of Saturable Hyperpolarized 13C Pyruvate Kinetics

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)
Secondary: Acquisition & Reconstruction - Pulse Sequence Design and Spatial Encoding Methods
666-01-011 · Hyperpolarization: Novel Methods · Thursday, 14 May, 8:30 AM–9:25 AM · Digital Posters Row G
Keywords: Michaelis-Menten Kinetic Modeling Hyperpolarized 13C
Accepted
Abubakr Eldirdiri1, Joshua Rogers1, Dirk Mayer1
1Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, United States of America
Presenting Author: Jiachen Zhuo

Synopsis

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References

1. Xu T, Mayer D, Gu M, Yen YF, Josan S, Tropp J, Pfefferbaum A, Hurd R, Spielman D. Quantification of in vivo metabolic kinetics of hyperpolarized pyruvate in rat kidneys using dynamic 13C MRSI. NMR in Biomedicine. 2011;24:997-1005. https://doi.org/10.1002/nbm.1719 [doi]
2. Larson PE, Kerr AB, Chen AP, Lustig MS, Zierhut ML, Hu S, Cunningham CH, Pauly JM, Kurhanewicz J, Vigneron DB. Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging. Journal of magnetic resonance. 2008;194:121-127. https://doi.org/10.1016/j.jmr.2008.06.010 [doi]
3. Zhao L, Mulkern R, Tseng CH, Williamson D, Patz S, Kraft R, Walsworth RL, Jolesz FA, Albert MS. Gradient-echo imaging considerations for hyperpolarized129Xe MR. Journal of Magnetic Resonance B. 1996;113:179-183.
4. Josan S, Spielman D, Yen YF, Hurd R, Pfefferbaum A, Mayer D. Fast volumetric imaging of ethanol metabolism in rat liver with hyperpolarized [1‐13C] pyruvate. NMR in Biomedicine. 2012;25:993-999. https://doi.org/10.1002/nbm.2762 [doi]
5. Larson PE, Chen HY, Gordon JW, Korn N, Maidens J, Arcak M, Tang S, Criekinge M, Carvajal L, Mammoli D, Bok R. Investigation of analysis methods for hyperpolarized 13C‐pyruvate metabolic MRI in prostate cancer patients. NMR in Biomedicine. 2018;31:e3997. https://doi.org/10.1002/nbm.3997 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/666-01-011