470-09-141 ISMRM Abstract

Characterization of regional variations in brain temperature and metabolite concentrations in people with HIV

Primary: Neuro - Infectious Disease

Secondary: Interventional - Thermometry/Thermotherapy

470-09-141 · MRI in Infectious Diseases · Tuesday, 12 May, 4:00 PM–4:55 PM · Traditional Posters | Exhibition Hall

Keywords: Brain metabolism HIV MR Spectroscopy (MRS) Brain Temperature MR Thermometry

Accepted

Kathryn G Malone ¹, Kaundinya Gopinath², Howard L Pope Jr.³, Alicarmen Alvarez³, Minh Ly Nguyen³, Taylor B Harrison⁴, Christina Gavegnano⁵, Vincent C Marconi^3,6, William Tyor⁴, Candace C Fleischer^1,2

¹Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, United States of America

²Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, United States of America

³Department of Medicine, Emory University School of Medicine, Atlanta, United States of America

⁴Department of Neurology, Emory University School of Medicine, Atlanta, United States of America

⁵Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United States of America

⁶Department of Global Health, Emory University, Rollins School of Public Health, United States of America

Presenting Author: Kathryn G Malone

Synopsis

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References

1. Yulug B, Velioglu HA, Sayman D, Cankaya S, Hanoglu L. Brain temperature in healthy and diseased conditions: A review on the special implications of MRS for monitoring brain temperature. Biomedicine & Pharmacotherapy. 2023;160:114287. doi: 10.1016/j.biopha.2023.114287. [doi]

2. Sung D, Risk BB, Wang KJ, Allen JW, Fleischer CC. Resting-state brain temperature: dynamic fluctuations in brain temperature and the brain-body temperature gradient. J Magn Reson Imaging. 2023;57(4):1222-8. doi: 10.1002/jmri.28376. [doi]

3. Chelala L, O'Connor EE, Barker PB, Zeffiro TA. Meta-analysis of brain metabolite differences in HIV infection. Neuroimage Clin. 2020;28:102436. doi: 10.1016/j.nicl.2020.102436. [doi]

4. O'Connor EE, Zeffiro TA, Zeffiro TA. Brain Structural Changes following HIV Infection: Meta-Analysis. AJNR Am J Neuroradiol. 2018;39(1):54-62. doi: 10.3174/ajnr.A5432. [doi]

5. Andersen AB, Law I, Krabbe KS, Bruunsgaard H, Ostrowski SR, Ullum H, et al. Cerebral FDG-PET scanning abnormalities in optimally treated HIV patients. J Neuroinflammation. 2010;7:13. doi: 10.1186/1742-2094-7-13. [doi]

6. Ances BM, Sisti D, Vaida F, Liang CL, Leontiev O, Perthen JE, et al. Resting cerebral blood flow: a potential biomarker of the effects of HIV in the brain. Neurology. 2009;73(9):702-8. doi: 10.1212/WNL.0b013e3181b59a97. [doi]

7. Thomas BP, Sheng M, Tseng BY, Tarumi T, Martin-Cook K, Womack KB, et al. Reduced global brain metabolism but maintained vascular function in amnestic mild cognitive impairment. J Cereb Blood Flow Metab. 2017;37(4):1508-16. doi: 10.1177/0271678x16658662. [doi]

8. Mintzopoulos D, Ratai EM, He J, Gonzalez RG, Kaufman MJ. Simian immunodeficiency virus transiently increases brain temperature in rhesus monkeys: detection with magnetic resonance spectroscopy thermometry. Magn Reson Med. 2019;81(5):2896-904. doi: 10.1002/mrm.27635. [doi]

9. Goryawala MZ, Sheriff S, Maudsley AA. Regional distributions of brain glutamate and glutamine in normal subjects. NMR Biomed. 2016;29(8):1108-16. doi: 10.1002/nbm.3575. [doi]

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http://echo.ismrm.org/p/ISMRM2026/470-09-141