Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
366-06-007 ISMRM Abstract

UTE-DESS-based Diffusion Tensor Imaging for Detecting Degeneration in Meniscus: An Ex Vivo Study

Accepted
Jinil Park 1, Sam Sedaghat2, Eddie Fu1, Stefan Sommer3,4, Lumeng Cui5, Youngkyoo Jung1, Abhijit Chaudhari1, Lorenzo Nardo1, Hyungseok Jang1
1Department of Radiology, University of California, Berkeley, United States of America
2Department of Radiology, University Hospital Heidelberg, Heidelberg, Germany
3Swiss Center for Musculoskeletal Imaging (SCMI), Zurich, Switzerland
4Swiss Innovation Hub, Siemens Healthineers International AG, Switzerland
5Siemens Healthcare Limited, Montreal, Canada
Presenting Author: Jinil Park

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Man GS, Mologhianu G. Osteoarthritis pathogenesis - a complex process that involves the entire joint. Journal of medicine and life. 2014;7(1):37-41.
2. Ozeki N, Koga H, Sekiya I. Degenerative Meniscus in Knee Osteoarthritis: From Pathology to Treatment. Life. 2022;12(4):1-14. doi:10.3390/life12040603 [doi]
3. Roos H, Adalberth T, Dahlberg L, Lohmander LS. Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age. Osteoarthritis and Cartilage. 1995;3(4):261-267. doi:10.1016/S1063-4584(05)80017-2 [doi]
4. Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: A disease of the joint as an organ. Arthritis & Rheumatism. 2012;64(6):1697-1707. doi:10.1002/art.34453 [doi]
5. Englund M, Guermazi A, Roemer FW, et al. Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: The Multicenter Osteoarthritis Study. Arthritis Rheum. 2009;60(3):831-839. doi:10.1002/art.24383 [doi]
6. Baum T, Joseph GB, Karampinos DC, Jungmann PM, Link TM, Bauer JS. Cartilage and meniscal T2 relaxation time as non-invasive biomarker for knee osteoarthritis and cartilage repair procedures. Osteoarthritis Cartilage. 2013;21(10):1474-1484. doi:10.1016/j.joca.2013.07.012 [doi]
7. Le J, Peng Q, Sperling K. Biochemical magnetic resonance imaging of knee articular cartilage: T1rho and T2 mapping as cartilage degeneration biomarkers. Annals of the New York Academy of Sciences. 2016;1383(1):34-42. doi:10.1111/nyas.13189 [doi]
8. Shao H, Pauli C, Li S, et al. Magic Angle Effect Plays a Major Role in Both T1rho and T2 Relaxation in Articular Cartilage. Osteoarthritis Cartilage. 2017;25(12):2022-2030. doi:10.1016/j.joca.2017.01.013 [doi]
9. Afsahi AM, Ma Y, Jang H, et al. Ultrashort Echo Time Magnetic Resonance Imaging Techniques: Met and Unmet Needs in Musculoskeletal Imaging. Journal of Magnetic Resonance Imaging. 2022;55(6):1597-1612. doi:10.1002/jmri.28032 [doi]
10. Park J, Sedaghat S, Fu E, et al. Diffusion Tensor Imaging of Short T2 Tissues Using Quantitative Ultrashort Echo Time Double Echo Steady State (qUTE-DESS): A Feasibility Study. NMR Biomed. 2025, In-Press.
11. Freed DE, Scheven UM, Zielinski LJ, Sen PN, Hürlimann MD. Steady-state free precession experiments and exact treatment of diffusion in a uniform gradient. The Journal of Chemical Physics. 2001;115(9):4249-4258. doi:10.1063/1.1389859 [doi]
12. Tristán-Vega A, Aja-Fernández S, Westin CF. Least Squares for Diffusion Tensor Estimation Revisited: Propagation of Uncertainty with Rician and non-Rician Signals. Neuroimage. 2012;59(4):4032-4043. doi:10.1016/j.neuroimage.2011.09.074 [doi]
13. Nissi MJ, Salo EN, Tiitu V, et al. Multi-parametric MRI characterization of enzymatically degraded articular cartilage. Journal of Orthopaedic Research. 2016;34(7):1111-1120. doi:10.1002/jor.23127 [doi]
14. Berg A, Singer T, Moser E. High-Resolution Diffusivity Imaging at 3.0 T for the Detection of Degenerative Changes: A Trypsin-Based Arthritis Model. Investigative Radiology. 2003;38(7):460-466. doi:10.1097/01.rli.0000078762.72335.57 [doi]
15. Wan L, Cheng X, Searleman AC, et al. Evaluation of enzymatic proteoglycan and collagen degradation in human articular cartilage using ultrashort echo time (UTE)-based biomarkers: a feasibility study. NMR Biomed. 2022;35(5):e4664. doi:10.1002/nbm.4664 [doi]

Cite this abstract