Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
552-01-003 / 552-01-003 ISMRM Abstract

Optimizing MRS tissue correction sensitized to aging-related neurometabolic differences in GABA+ and Glx

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Neuro - Aging
552-01-003 · Novel Approaches to Spectroscopy · Wednesday, 13 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2
552-01-003 · Novel Approaches to Spectroscopy · Wednesday, 13 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2
Keywords: Aging MRS Gamma-aminobutyric acid Excitatory-inhibitory balance
Accepted
Lisa C Krishnamurthy 1,2, Venkatagiri Krishnamurthy2,3,4,5
1Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, United States of America
2Research Service Line, Department of Veterans Affairs, United States of America
3Medicine, Emory University, Atlanta, United States of America
4Department of Medicine, Emory University School of Medicine, Atlanta, United States of America
5Department of Veterans Affairs, United States of America
Presenting Author: Lisa C Krishnamurthy

Synopsis

Motivation:
Results:
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References

1. 1. Yokoyama, H. and K. Kitajo, A data assimilation method to track excitation-inhibition balance change using scalp EEG. Communications Engineering, 2023. 2(1): p. 92.
2. 2. Yang, B., et al., Natural brain state change with E/I balance shifting toward inhibition is associated with vigilance impairment. iScience, 2023. 26(10): p. 107963.
3. 3. Karst, H., et al., Age-dependent shift in spontaneous excitation-inhibition balance of infralimbic prefrontal layer II/III neurons is accelerated by early life stress, independent of forebrain mineralocorticoid receptor expression. Neuropharmacology, 2020. 180: p. 108294.
4. 4. Chen, X., et al., Neural Excitatory/Inhibitory Imbalance in Motor Aging: From Genetic Mechanisms to Therapeutic Challenges. Biology (Basel), 2025. 14(3).
5. 5. Harris, A.D., N.A. Puts, and R.A. Edden, Tissue correction for GABA-edited MRS: Considerations of voxel composition, tissue segmentation, and tissue relaxations. J Magn Reson Imaging, 2015. 42(5): p. 1431-40.
6. 6. Krishnamurthy, V. and L.C. Krishnamurthy, CBF gradient and excitatory-inhibitory balance measured from pre-SMA - importance in aging and semantic fluency task difficulties. Neuroimage, 2025. 320: p. 121451.
7. 7. Gruetter, R., Automatic, localized in vivo adjustment of all first- and second-order shim coils. Magn Reson Med, 1993. 29(6): p. 804-11.
8. 8. Gruetter, R. and I. Tkac, Field mapping without reference scan using asymmetric echo-planar techniques. Magn Reson Med, 2000. 43(2): p. 319-23.
9. 9. Provencher, S.W., Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed, 2001. 14(4): p. 260-4.
10. 10. Edden, R.A., et al., Gannet: A batch-processing tool for the quantitative analysis of gamma-aminobutyric acid-edited MR spectroscopy spectra. J Magn Reson Imaging, 2014. 40(6): p. 1445-52.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/552-01-003