Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
470-09-144 ISMRM Abstract

White Matter Microstructural Alterations in Neurological Post-Acute Sequelae of COVID-19 Indicate Neuroinflammation

Primary: Neuro - Infectious Disease
Secondary: Neuro - Neuroinflammation
470-09-144 · MRI in Infectious Diseases · Tuesday, 12 May, 4:00 PM–4:55 PM · Traditional Posters | Exhibition Hall
Keywords: COVID-19 PASC
Accepted
Chuan Huang1, Xinlan Zhang1, Jia Ying1,2, Zennur Sekendiz3, Ashley Fontana3, Xiaohua Yang3, Steven West3, Paul Vaska2,4, Sean A Clouston5,6, Benjamin Luft3
1Radiology & Imaging Sciences, Emory University, Atlanta, United States of America
2Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, United States of America
3Department of Medicine, Division on Infectious Diseases, State University of New York at Stony Brook, Stony Brook, United States of America
4Radiology, State University of New York at Stony Brook, Stony Brook, United States of America
5Program in Public Health, State University of New York at Stony Brook, Stony Brook, United States of America
6Department of Family, Population, and Preventive Medicine, State University of New York at Stony Brook, Stony Brook, United States of America
Presenting Author: Sixuan Guo

Synopsis

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References

1. Nalbandian, A., et al., Post-acute COVID-19 syndrome. Nature medicine, 2021. 27(4): p. 601-615.
2. Takao, M. and M. Ohira, Neurological post-acute sequelae of SARS-CoV-2 infection. Psychiatry Clin Neurosci, 2023. 77(2): p. 72-83.
3. Luft, B.J., et al., Exposure, probable PTSD and lower respiratory illness among World Trade Center rescue, recovery and clean-up workers. Psychol Med, 2012. 42(5): p. 1069-79.
4. Clouston, S.A.P., et al., Reduced cortical thickness in World Trade Center responders with cognitive impairment: Neuroimaging/differential diagnosis. Alzheimer's & Dementia, 2020. 16: p. e039996.
5. Deri, Y., et al., Neuroinflammation in World Trade Center responders at midlife: A pilot study using [(18)F]-FEPPA PET imaging. Brain Behav Immun Health, 2021. 16: p. 100287.
6. Budde, M.D., et al., Toward accurate diagnosis of white matter pathology using diffusion tensor imaging. Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine, 2007. 57(4): p. 688-695.
7. Kono, K., et al., The role of diffusion-weighted imaging in patients with brain tumors. American journal of neuroradiology, 2001. 22(6): p. 1081-1088.
8. Shenton, M.E., et al., A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain imaging and behavior, 2012. 6: p. 137-192.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/470-09-144