Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
430-04-010 ISMRM Abstract

Effects of gadolinium deposition on transcriptome levels in skin: a dual model of rats and mice

Primary: Contrast Mechanisms - Contrast Agents
Secondary: Preclinical Animal & in vitro MR - Small Animals
430-04-010 · Cardiovascular and Body Imaging · Tuesday, 12 May, 4:00 PM–5:50 PM · Meeting Room 2.60
Accepted
Chuan bing Wang 1, Shouju Wang2,3
1Radiology, the First Affiliated Hospital With Nanjing Medical University (Jiangsu Province Hospital), Nan jing, China
2Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
3Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
Presenting Author: Chuan bing Wang

Synopsis

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References

1. 27.Hamrani D, Vives V, Buchholz R, et al. Effect of long-term retention of gadolinium on metabolism of deep cerebellar nuclei after repeated injections of gadodiamide in rats. Invest Radiol. 2020;55(2):120-128.
2. 28.Ghorbanalipoor S, Hommel T, Kolbe T, et al. The loss of keratin 77 in murine skin is functionally compensated by keratin 1. Biochim Biophys Acta Mol Cell Res. 2025;1872(2):119-126.
3. 1.Leclerc EA, Huchenq A, Kezic S, Serre G, Jonca N. Mice deficient for the epidermal dermokine β and γ isoforms display transient cornification defects. J Cell Sci. 2014;127(13):2862-2872.
4. 2.De Juanes S, Epp N, Latzko S, et al. Development of an ichthyosiform phenotype in Alox12b-deficient mouse skin transplants. J Invest Dermatol. 2009;129(6):1429-1436.
5. 3.Hao D, Ai T, Goerner F, et al. MRI contrast agents: Basic chemistry and safety. J Magn Reson Imaging. 2012;36(5):1060-1071.
6. 4.Delfino R, Biasotto M, Candido R, et al. Gadolinium tissue deposition in the periodontal ligament of mice with reduced renal function exposed to Gd-based contrast agents. Toxicol Lett. 2019;301:157-167.
7. 5.Strzeminska I, Factor C, Robert P, et al. Long-Term Evaluation of Gadolinium Retention in Rat Brain After Single Injection of a Clinically Relevant Dose of Gadolinium-Based Contrast Agents. Invest Radiol. 2020;55(3):138-143.
8. 6.Frenzel T, Lengsfeld P, Schirmer H, et al. Stability of Gadolinium-Based Magnetic Resonance Imaging Contrast Agents in Human Serum at 37°C. Invest Radiol. 2008;43(12):817-828.
9. 7.van der Molen AJ, Quattrocchi CC, Mallio CA, et al. Ten years of gadolinium retention and deposition: ESMRMB-GREC looks backward and forward [published correction appears in Eur Radiol. 2024;34(1):728. Eur Radiol. 2024;34(1):600-611.
10. 8.McDonald J, McDonald R. MR imaging safety considerations of gadolinium-based contrast agents. Magn Reson Imaging Clin N Am. 2020;28(4):497-507.
11. 9.Funke SKI, Factor C, Rasschaert M, et al. Long-term Gadolinium Retention in the Healthy Rat Brain: Comparison between Gadopiclenol, Gadobutrol, and Gadodiamide. Radiology. 2022;305(1):179-189.
12. 10.El Hamrani D, Vives V, Buchholz R, et al. Effect of Long-Term Retention of Gadolinium on Metabolism of Deep Cerebellar Nuclei After Repeated Injections of Gadodiamide in Rats. Invest Radiol. 2020;55(2):120-128.
13. 11.22.Richter H, Bücker P, Martin LF, et al. Gadolinium Tissue Distribution in a Large-Animal Model after a Single Dose of Gadolinium-based Contrast Agents. Radiology. 2021;301(3):637-642.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/430-04-010