Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
564-03-010 ISMRM Abstract

Altered Segregation and Integration of Brain Networks in Insomnia Disorder Patients with and without Depression

Primary: Neuro - Psychiatric Disorders
Secondary: Brain Function and fMRI - fMRI Analysis
564-03-010 · fMRI: Development and Aging · Wednesday, 13 May, 1:40 PM–2:35 PM · Digital Posters Row E
Keywords: Depression Insomnia disorder Segregation Integration
Accepted
Hui Wang 1,2, Gengchen Ye2, Haoyu Chen3, Yuanyuan Liu3, Kai AI4, Wei Sheng5, Wei Chen6, Rong Wang7, Ming Zhang1,2
1School of Future Technology, Xi'an Jiaotong University, Xi'an, China
2Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
3Xi'an Jiaotong University, Xi'an, China
4Department of Clinical and Technical Support, Philips Healthcare (Xi'an), Xi'an, China
5MR Research Collaboration Team, Siemens Healthineers Ltd., Chengdu, China
6Department of Medical Imaging Center, Ankang Hospital of Traditional Chinese Medicine, China
7School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an, China
Presenting Author: Hui Wang

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References

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2. Wang, X., Z. Chang and R. Wang, Opposite effects of positive and negative symptoms on resting-state brain networks in schizophrenia. Commun Biol, 2023. 6(1): p. 279. doi: 10.1038/s42003-023-04637-0. [doi]
3. Shine, J.M., Neuromodulatory Influences on Integration and Segregation in the Brain. Trends Cogn Sci, 2019. 23(7): p. 572-583. doi: 10.1016/j.tics.2019.04.002. [doi]
4. Wang, R., et al., Segregation, integration, and balance of large-scale resting brain networks configure different cognitive abilities. Proc Natl Acad Sci U S A, 2021. 118(23). doi: 10.1073/pnas.2022288118. [doi]
5. Wang, R., et al., Lifespan associations of resting-state brain functional networks with ADHD symptoms. iScience, 2022. 25(7): p. 104673. doi: 10.1016/j.isci.2022.104673. [doi]
6. Chen, M., et al., Aberrant individual large-scale functional network connectivity and topology in chronic insomnia disorder with and without depression. Prog Neuropsychopharmacol Biol Psychiatry, 2025. 136: p. 111158. doi: 10.1016/j.pnpbp.2024.111158. [doi]
7. Chiappelli, J., et al., Depression, stress and regional cerebral blood flow. J Cereb Blood Flow Metab, 2023. 43(5): p. 791-800. doi: 10.1177/0271678X221148979. [doi]
8. Yu, L., et al., Cerebral Blood Flow Changes and Their Spatial Correlations With GABAa and Dopamine-D1 Receptor Explaining Individual Differences in Chronic Insomnia and the Therapeutic Effects of Acupuncture. Hum Brain Mapp, 2025. 46(4): p. e70183. doi: 10.1002/hbm.70183. [doi]
9. Banaszkiewicz, A., et al., The role of the superior parietal lobule in lexical processing of sign language: Insights from fMRI and TMS. Cortex, 2021. 135: p. 240-254. doi: 10.1016/j.cortex.2020.10.025. [doi]
10. Javaheripour, N., et al., Functional brain alterations in acute sleep deprivation: An activation likelihood estimation meta-analysis. Sleep Med Rev, 2019. 46: p. 64-73. doi: 10.1016/j.smrv.2019.03.008. [doi]
11. Zheng, H., et al., Altered functional connectivity of the default mode and frontal control networks in patients with insomnia. CNS Neurosci Ther, 2023. 29(8): p. 2318-2326. doi: 10.1111/cns.14183. [doi]
12. Zhang, L., et al., Altered cerebral functional activity and its associated genetic profiles underlying chronic insomnia disorder before and after treatment. World J Biol Psychiatry, 2025. 26(5): p. 211-223. doi: 10.1080/15622975.2025.2503938. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/564-03-010