Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
564-02-011 ISMRM Abstract

Validation of Quantitative MR-ARFI for Acoustic Dosimetry in Transcranial Ultrasound Stimulation

Primary: Interventional - MR-Guided Focused Ultrasound
Secondary: Neuro - Neuromodulation
564-02-011 · Interventional MRI: General · Wednesday, 13 May, 9:15 AM–10:10 AM · Digital Posters Row E
Keywords: Focused Ultrasound MR-Guided Interventions Transcranial focused ultrasound Transcranial ultrasound neuromodulation
Accepted
Kristen Zarcone 1, Charles F Caskey2,3, William A Grissom1,4,5
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, United States of America
2Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt University Institute of Imaging Science, Nashville, United States of America
4Case Western University, Chapel Hill, United States of America
5Case Western Reserve University, Cleveland, United States of America
Presenting Author: Kristen Zarcone

Synopsis

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References

1. J. J. Mahoney et al., “Low-Intensity Focused Ultrasound Targeting the Bilateral Nucleus Accumbens as a Potential Treatment for Substance Use Disorder: A First-in-Human Report,” Biological Psychiatry, vol. 94, no. 11, pp. e41–e43, Dec. 2023, doi: 10.1016/j.biopsych.2023.06.031. [doi]
2. W. Legon et al., “Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans,” Nat Neurosci, vol. 17, no. 2, pp. 322–329, Feb. 2014, doi: 10.1038/nn.3620. [doi]
3. H. Baek et al., “Clinical Intervention Using Focused Ultrasound (FUS) Stimulation of the Brain in Diverse Neurological Disorders,” Frontiers in Neurology, vol. 13, May 2022, doi: 10.3389/fneur.2022.880814. [doi]
4. K. Lee, T. Y. Park, W. Lee, and H. Kim, “A review of functional neuromodulation in humans using low-intensity transcranial focused ultrasound,” Biomed. Eng. Lett., vol. 14, no. 3, pp. 407–438, May 2024, doi: 10.1007/s13534-024-00369-0. [doi]
5. U.S. Food and Drug Administration, Guidance for Industry and FDA Staff: Information for Manufacturers Seeking Marketing Clearance of Diagnostic Ultrasound Systems and Transducers, Silver Spring, MD: Center for Devices and Radiological Health, 2008. [Online]. Available: https://www.fda.gov/media/71100/download
6. P.-F. Yang et al., “Differential dose responses of transcranial focused ultrasound at brain regions indicate causal interactions,” Brain Stimulation, vol. 15, no. 6, pp. 1552–1564, Nov. 2022, doi: 10.1016/j.brs.2022.12.003. [doi]
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8. A. Farrer et al., “Characterization and evaluation of tissue-mimicking gelatin phantoms for use with MRgFUS,” Journal of therapeutic ultrasound, vol. 3, p. 9, July 2015, doi: 10.1186/s40349-015-0030-y. [doi]
9. [1] N. Li, P. Gaur, K. Quah, and K. Butts Pauly, “Improving in situ acoustic intensity estimates using MR acoustic radiation force imaging in combination with multifrequency MR elastography,” Magnetic Resonance in Medicine, vol. 88, no. 4, pp. 1673–1689, Oct. 2022, doi: 10.1002/mrm.29309. [doi]
10. H. Luo et al., “Reduced-field of view three-dimensional MR acoustic radiation force imaging with a low-rank reconstruction for targeting transcranial focused ultrasound,” Magnetic Resonance in Medicine, vol. 88, no. 6, pp. 2419–2431, 2022, doi: 10.1002/mrm.29403. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/564-02-011