Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
430-04-006 ISMRM Abstract

Dynamic mapping of Glc oxidative metabolism in young rats with chronic liver disease using 1H-2H-FID-MRSI at 9.4T

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Contrast Mechanisms - Deuterium
430-04-006 · Cardiovascular and Body Imaging · Tuesday, 12 May, 4:00 PM–5:50 PM · Meeting Room 2.60
Keywords: Glucose metabolism Preclinical MRS Indirect 2H detection Chronic Hepatic Encephalopathy 9.4T MRSI
Accepted
Gianna Nossa 1,2, Alessio Siviglia1,2, Dario Sessa3, Estelle Gerossier1,2, jocelyn Grosse1,2, Cristina Cudalbu1,2, Bernard Lanz1,2
1CIBM Pre-Clinical Imaging EPFL, Lausanne, Switzerland
2CIBM Center for BioMedical Imaging, Lausanne, Switzerland, Switzerland
3Swiss Pediatric Liver Center, Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerland, Switzerland
Presenting Author: Gianna Nossa

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. 1. Prasad SK, Acharjee A, Singh VV, Trigun SK, Acharjee P. Modulation of brain energy metabolism in hepatic encephalopathy: impact of glucose metabolic dysfunction. Metab Brain Dis. 2024;39(8):1649-1665. doi:10.1007/s11011-024-01407-7 [doi]
2. 2. Sørensen M, Andersen JV, Bjerring PN, Vilstrup H. Hepatic encephalopathy as a result of ammonia-induced increase in GABAergic tone with secondary reduced brain energy metabolism. Metab Brain Dis. 2025;40(1):19. doi:10.1007/s11011-024-01473-x [doi]
3. 3. Mosso J, Yin T, Poitry-Yamate C, et al. PET CMRglc mapping and 1H-MRS show altered glucose uptake and neurometabolic profiles in BDL rats. Anal Biochem. 2022;647:114606. doi:10.1016/j.ab.2022.114606 [doi]
4. 4. Rackayova V, Braissant O, McLin VA, Berset C, Lanz B, Cudalbu C. 1H and 31P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolism. Metab Brain Dis. 2016;31(6):1303-1314. doi:10.1007/s11011-015-9715-8 [doi]
5. 5. Lanz B. In vivo 13C MRS investigation of alterations in cerebral oxidative metabolism in a chronic liver disease rat model. Presented at: International Society for Magnetic Resonance in Medicine 2013.
6. 6. De Feyter HM, Behar KL, Corbin ZA, et al. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Sci Adv. 2018;4(8):eaat7314. doi:10.1126/sciadv.aat7314 [doi]
7. 7. Lu M, Zhu XH, Zhang Y, Mateescu G, Chen W. Quantitative assessment of brain glucose metabolic rates using in vivo deuterium magnetic resonance spectroscopy. J Cereb Blood Flow Metab. 2017;37(11):3518-3530. doi:10.1177/0271678X17706444 [doi]
8. 8. Roig ES, De Feyter HM, Nixon TW, et al. Deuterium Metabolic Imaging (DMI) of the Human Brain in vivo at 7T. Magn Reson Med. 2023;89(1):29-39. doi:10.1002/mrm.29439 [doi]
9. 9. Ruhm L, Avdievich N, Ziegs T, et al. Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution. Neuroimage. 2021;244:118639. doi:10.1016/j.neuroimage.2021.118639 [doi]
10. 10. Veltien A, van Asten J, Ravichandran N, et al. Simultaneous Recording of the Uptake and Conversion of Glucose and Choline in Tumors by Deuterium Metabolic Imaging. Cancers. 2021;13(16):4034. doi:10.3390/cancers13164034 [doi]
11. 11. Simicic D, Pierzchala K, Rackayová V, et al. P: 33 In Vivo Longitudinal 1H MRS Study of Hippocampal, Cereberal and Striatal Metabolic Changes in the Adult Brain Using an Animal Model of Chronic Hepatic Encephalopathy. Off J Am Coll Gastroenterol ACG. 2019;114:S17. doi:10.14309/01.ajg.0000582108.29364.13 [doi]
12. 12. DeMorrow S, Cudalbu C, Davies N, Jayakumar A, Rose C. 2021 ISHEN Guidelines on Animal Models of Hepatic Encephalopathy. Liver Int Off J Int Assoc Study Liver. 2021;41(7):1474-1488. doi:10.1111/liv.14911 [doi]
13. 13. Lanz B, Duarte JMN, Kunz N, Mlynárik V, Gruetter R, Cudalbu C. Which prior knowledge? Quantification of in vivo brain 13C MR spectra following 13C glucose infusion using AMARES. Magn Reson Med. 2013;69(6):1512-1522. doi:10.1002/mrm.24406 [doi]
14. 14. AlvBrayan. AlvBrayan/MRS4Brain-toolbox. Published online October 22, 2025. Accessed October 30, 2025. https://github.com/AlvBrayan/MRS4Brain-toolbox
15. 15. Provencher SW. Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed. 2001;14(4):260-264. doi:10.1002/nbm.698 [doi]
16. 16. Starčuk Z, Starčuková J. Quantum-mechanical simulations for in vivo MR spectroscopy: Principles and possibilities demonstrated with the program NMRScopeB. Anal Biochem. 2017;529:79-97. doi:10.1016/j.ab.2016.10.007 [doi]
17. 17. Siviglia A. Dynamic mapping of Glc oxidative metabolism in rats with indirect 1H-FID-MRSI deuterium detection at 9.4T. Presented at: International Society for Magnetic Resonance in Medicine 2025.
18. 18. Henry PG, Lebon V, Vaufrey F, Brouillet E, Hantraye P, Bloch G. Decreased TCA cycle rate in the rat brain after acute 3-NP treatment measured by in vivo1H-13C NMR spectroscopy. J Neurochem. 2002;82(4):857-866. doi:10.1046/j.1471-4159.2002.01006.x [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/430-04-006