562-06-013 ISMRM Abstract

Mapping Brain-Wide Functional Connectivity in an Awake Schizophrenic Mouse Model

Primary: Preclinical Animal & in vitro MR - Small Animals

Secondary: Brain Function and fMRI - Functional Connectivity

562-06-013 · fMRI: Preclinical · Wednesday, 13 May, 4:55 PM–5:50 PM · Digital Posters Row C

Keywords: Schizophrenia Rs-fMRI Awake animal fMRI Multi-modal imaging Anterior cingulate cortex

Accepted

Nivetha Pasupathy ¹, David Hike¹, Xiaochen Liu¹, Charles Reilly¹, William Xu¹, Yuanyuan Jiang¹, Jen Q Pan², Xin Yu¹, Xiaoqing A Zhou¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America

²Stanley Center for Psychiatric Research,, Broad Institute of MIT and Harvard, Cambridge, United States of America

Presenting Author: Nivetha Pasupathy

Synopsis

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References

1. Halassa, M. M., Chen, Z., Wimmer, R. D., Brunetti, P. M., Zhao, S., Zikopoulos, B., Wang, F., Brown, E. N., & Wilson, M. A. (2014). State-dependent architecture of thalamic reticular subnetworks. Cell, 158(4), 808–821. https://doi.org/10.1016/j.cell.2014.06.025 [doi]

2. Ghoshal, A., Uygun, D. S., Yang, L., Newton, S. S., Miller, B. R., Yeom, A. S., Villalobos, J., Wang, J., Manor, U., Fetter, R. D., Lasarge, C., Yue, Y., Dumont, J. R., Perez-Reyes, E., & Pan, J. Q. (2020). Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits. Translational Psychiatry, 10, 29. https://doi.org/10.1038/s41398-020-0685-1 [doi]

3. Pais-Roldán, P., Takahashi, K., Sobczak, F., Chen, Y., Zhao, X., Zeng, H., & Yu, X. (2020). Indexing brain state–dependent pupil dynamics with simultaneous fMRI and optical fiber calcium recording. Proceedings of the National Academy of Sciences, 117(12), 6875–6882. https://doi.org/10.1073/pnas.1909937117 [doi]

4. Hike, D., Liu, X., Xie, Z., Zhang, B., Choi, S., Zhou, X. A., & Yu, X. (2024). High-resolution awake mouse fMRI at 14 Tesla. eLife, 13, e101234. https://doi.org/10.7554/eLife.95528.2 [doi]

5. Andrade, A., Hope, J., Allen, A., Yorgan, V., Lipscombe, D., & Pan, J. Q. (2016). A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity. Scientific Reports, 6, 34233. https://doi.org/10.1038/srep34233 [doi]

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http://echo.ismrm.org/p/ISMRM2026/562-06-013