Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-03-002 ISMRM Abstract

Glymphatic Failure Mediates Multisystem Neurodegeneration in ALS: Motor System Injury and Cognitive Dysfunction

Primary: Neuro - Other Neurodegeneration
Secondary: Neuro - Neurofluids
663-03-002 · Glymphatic System Imaging: From Neurofluid Transport to Neurodegeneration · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row D
Keywords: Perivascular spaces Choroid plexus volume Amyotrophic lateral sclerosis Glymphatic Function DTI-ALPS index
Accepted
Shan Wu 1, Tao Lu1,2, Haining Li2, Qianqian Duan2, Xinyi Yu2, ningkun hou1,2, Fangfang Hu1,3, Jiaoting Jin3, Weixia Mao4, Jia Zhe4, bao qin guo5, Qiuli Zhang1, Ming Zhang1,2,6
1Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
2The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
3Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
4Department of CT, Yulin Hospital The First Affiliated Hospital of Xi’an Jiaotong University, China
5Yulin Hospital The First Affiliated Hospital of Xi’an Jiaotong University, China
6School of Future Technology, Xi'an Jiaotong University, Xi'an, China
Presenting Author: Shan Wu

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Ng Kee Kwong, K. C., Mehta, A. R., Nedergaard, M. & Chandran, S. Defining novel functions for cerebrospinal fluid in ALS pathophysiology. Acta Neuropathol Commun 8, 140, doi:10.1186/s40478-020-01018-0 (2020). [doi]
2. Rasmussen, M. K., Mestre, H. & Nedergaard, M. The glymphatic pathway in neurological disorders. Lancet Neurol 17, 1016-1024, doi:10.1016/s1474-4422(18)30318-1 (2018). [doi]
3. Boland, B. et al. Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nat Rev Drug Discov 17, 660-688, doi:10.1038/nrd.2018.109 (2018). [doi]
4. Feldman, E. L. et al. Amyotrophic lateral sclerosis. Lancet 400, 1363-1380, doi:10.1016/s0140-6736(22)01272-7 (2022). [doi]
5. van Es, M. A. et al. Amyotrophic lateral sclerosis. Lancet 390, 2084-2098, doi:10.1016/s0140-6736(17)31287-4 (2017). [doi]
6. Collins, M. A., An, J., Hood, B. L., Conrads, T. P. & Bowser, R. P. Label-Free LC-MS/MS Proteomic Analysis of Cerebrospinal Fluid Identifies Protein/Pathway Alterations and Candidate Biomarkers for Amyotrophic Lateral Sclerosis. J Proteome Res 14, 4486-4501, doi:10.1021/acs.jproteome.5b00804 (2015). [doi]
7. Wuolikainen, A. et al. Multi-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects. Mol Biosyst 12, 1287-1298, doi:10.1039/c5mb00711a (2016). [doi]
8. Xie, L. et al. Sleep drives metabolite clearance from the adult brain. Science 342, 373-377, doi:10.1126/science.1241224 (2013). [doi]
9. Diaz-Abad, M. et al. Poor Sleep Quality in Patients With Amyotrophic Lateral Sclerosis at the Time of Diagnosis. J Clin Neuromuscul Dis 20, 60-68, doi:10.1097/cnd.0000000000000234 (2018). [doi]
10. Panda, S., Gourie-Devi, M. & Sharma, A. Sleep disorders in amyotrophic lateral sclerosis: A questionnaire-based study from India. Neurol India 66, 700-708, doi:10.4103/0028-3886.232327 (2018). [doi]
11. Wardlaw, J. M. et al. Perivascular spaces in the brain: anatomy, physiology and pathology. Nat Rev Neurol 16, 137-153, doi:10.1038/s41582-020-0312-z (2020). [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/663-03-002