Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
460-06-009 ISMRM Abstract

Choroid Plexus Cyst Enlargement Correlates with Lower DTI-ALPS Index in Parkinson’s Disease with Freezing of Gait

Primary: Neuro - Parkinson's Disease
Secondary: Neuro - Neurofluids
460-06-009 · Imaging the Brain’s Microenvironment: From Glymphatics to Cognition · Tuesday, 12 May, 4:55 PM–5:50 PM · Digital Posters Row A
Keywords: Parkinson's Disease DTI-ALPS index Choroid plexus cysts (CPCs)
Accepted
Suyi Zhou 1, Zhiming Zhen1, Dandan Yuan1, Fengwei Yu1, Taotao Yang1, Siyao Xu2, Chenghao Cao3, Ying-Hua Chu4, Yi-Cheng Hsu4, Huilin Pang1, zilong Li1, Peiyu Huang5, Heqing Huang6, Wei Chen1
17T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China
2Beijing Tiantan Hospital, Capital Medical University, Beijing, China
3West China Hospital of Sichuan University, Chengdu, China
4MR Research Collaboration Team, Shanghai, China
5Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Medical Psychology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China
Presenting Author: Suyi Zhou

Synopsis

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References

1. Nutt JG, Bloem BR, Giladi N, Hallett M, Horak FB, Nieuwboer A. Freezing of gait: Moving forward on a mysterious clinical phenomenon. Lancet Neurol. 2011;10(8):734-744.
2. Hatcher-Martin JM, McKay JL, Pybus AF, et al. Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: An exploratory analysis. NPJ Parkinsons Dis. 2021;7:105.
3. Kim R, Lee J, Kim H-J, et al. CSF β-amyloid42 and risk of freezing of gait in early Parkinson disease. Neurology. 2019;92(1):e40-e47.
4. Saunders NR, Dziegielewska KM, Fame RM, Lehtinen MK, Liddelow SA. The choroid plexus: A missing link in our understanding of brain development and function. Physiol Rev. 2023;103(2):919-956.
5. Hidaka Y, Hashimoto M, Suehiro T, et al. Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia. Fluids Barriers CNS. 2024;21:101.
6. Jeong SH, Park CJ, Jeong H-J, et al. Association of choroid plexus volume with motor symptoms and dopaminergic degeneration in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2023;jnnp-2023-331170.
7. Zhen Z, Zhang R, Gui L, et al. Choroid plexus cysts on 7T MRI: Relationship to aging and neurodegenerative diseases. Alzheimers Dement. 2024;[Epub ahead of print].
8. Liu X, Barisano G, Shao X, et al. Cross-vendor test-retest validation of DTI-ALPS for evaluating glymphatic system function. Aging Dis. 2024;15(7):1885-1898.
9. Bates CA, Zheng W. Brain disposition of α-synuclein: Roles of brain barrier systems and implications for Parkinson’s disease. Fluids Barriers CNS. 2014;11:17.
10. Delvenne A, Vandendriessche C, Gobom J, et al. Involvement of the choroid plexus in Alzheimer’s disease pathophysiology: Findings from mouse and human proteomic studies. Fluids Barriers CNS. 2024;21:58.
11. Vargas T, Ugalde C, Spuch C, et al. Abeta accumulation in choroid plexus is associated with mitochondrial-induced apoptosis. Neurobiol Aging. 2010;31(9):1569-1581.
12. González-Marrero I, Giménez-Llort L, Johanson CE, et al. Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer’s disease. Front Cell Neurosci. 2015;9:17.
13. Johanson C, Stopa E, McMillan P, et al. The distributional nexus of choroid plexus to CSF, ependyma and brain. Toxicol Pathol. 2011;39(1):186-212.
14. Jovanović I, Ugrenović S, Vasović L, Petrović D, Cekić S. Psammoma bodies—friends or foes of the aging choroid plexus. Med Hypotheses. 2010;74(6):1017-1020.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/460-06-009