Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
367-01-004 ISMRM Abstract

Lipid and Acetyl Carnitine Differences measured before and after GLP-1 induced weight loss at 7T with 1H-MRS

Primary: Musculoskeletal - Muscle
Secondary: Body - Metabolism
367-01-004 · Fuel and Function: Metabolism in the Body · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row H
Keywords: MRS Obesity Weight-loss Intramyocellular Lipids Metabolic pathways
Accepted
Ryan Armbruster1,2, neil wilson2,3, Aylin Ergin4, Anne R Cappola5, Anastassia Amaro5, Ravinder Reddy2,3
1Department of Bioengineering, University of Pennsylvania, Philadelphia, United States of America
2Center for Advanced Metabolic Imaging in Precision Medicine, University of Pennsylvania, Philadelphia, United States of America
3Department of Radiology, University of Pennsylvania, Philadelphia, United States of America
4University of Pennsylvania, Philadelphia, United States of America
5Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania, Philadelphia, United States of America
Presenting Author: Mark A Elliott

Synopsis

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References

1. 1. Conte C., Hall K. D., Klein S. *Is Weight Loss–Induced Muscle Mass Loss Clinically Relevant?* JAMA. 2024 Jul 2;332(1):9-10. DOI: 10.1001/jama.2024.6586. PMID: 38829659. [doi] [pmid]
2. 2. Alba D. L., et al. *Changes in Lean Mass, Absolute and Relative Muscle Strength, and Physical Performance After Gastric Bypass Surgery.* J Clin Endocrinol Metab. 2019;104(3):711-720. DOI: 10.1210/jc.2018-00952. PMID: 30657952. [doi] [pmid]
3. 3. Scheenen T. W. J., Klomp D. W. J., Wijnen J. P., Heerschap A. *Short echo time 1H-MRSI of the human brain at 3T with minimal chemical shift displacement errors using adiabatic refocusing pulses.* Magn Reson Med. 2008;59:1-6. DOI: 10.1002/mrm.21302. PMID: 17969076. [doi] [pmid]
4. Scheenen T. W. J., Klomp D. W. J., Wijnen J. P., Heerschap A. Short echo time 1H-MRSI of the human brain at 3T with minimal chemical shift displacement errors using adiabatic refocusing pulses. Magn Reson Med. 2008;59:1-6. DOI: 10.1002/mrm.21302. PMID: 17969076. [doi] [pmid]
5. 5. Ren J., Sherry A. D., Malloy C. R. *1H MRS of intramyocellular lipids in soleus muscle at 7 T: Spectral simplification by using long echo times without water suppression.* Magn Reson Med. 2010;64:662-671. DOI: 10.1002/mrm.22345. PMID: 20578068. [doi] [pmid]
6. 6. Krššák M., et al. *Proton magnetic resonance spectroscopy in skeletal muscle: Experts’ consensus recommendations.* NMR Biomed. 2021;34:e4266. DOI: 10.1002/nbm.4266. PMID: 32022964. [doi] [pmid]
7. 7. Gray R. E., Tanner C. J., Pories W. J., MacDonald K. G., Houmard J. A. *Effect of weight loss on muscle lipid content in morbidly obese subjects.* Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E726-E732. DOI: 10.1152/ajpendo.00371.2002. PMID: 12488242. [doi] [pmid]
8. 8. Tamura Y., et al. *Effects of Diet and Exercise on Muscle and Liver Intracellular Lipid Contents and Insulin Sensitivity in Type 2 Diabetic Patients.* J Clin Endocrinol Metab. 2005 Jun;90(6):3191-3196. DOI: 10.1210/jc.2004-1959. PMID: 15769987. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/367-01-004