651-02-003 / 651-02-003 ISMRM Abstract

SANDI diffusion imaging for brain tumor microstructure: clinical feasibility and initial histopathological validation

Primary: Diffusion - Microstructure

Secondary: Neuro - Tumors

651-02-003 · Diffusion Modeling To Map Tissue Microstructure · Thursday, 14 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1

Keywords: Microstructural imaging SANDI model Brain Tumor Imaging Diffusion-weighted imaging (DWI)

Accepted

Giovanni Savini ^1,2, Luca A Cappellini^1,2, Nadia Milanesi^1,3, Francesca Geroli², Luca Raspagliesi^1,2, gaia ressa^1,2, Riccardo Levi^1,2, Alessia Lindemann¹, Thorsten Feiweier⁴, DOMENICO ZACA'⁵, Matteo Battocchio^6,7, Clorindo Notte⁶, Pietro Bontempi^6,7, Marco Riva^1,2, Federico Pessina^1,2, Letterio S Politi^1,2

¹Humanitas University, Pieve Emanuele, Italy

²IRCCS Humanitas Research Hospital, Rozzano, Italy

³Consiglio Nazionale delle Ricerche, Milano, Italy

⁴MR Research and Clinical Translation, Siemens Healthineers AG, Erlangen, Germany

⁵Scientific Collaborations and Strategic Partnerships, Siemens Healthcare srl, Milano, Italy

⁶DICEtech Srl, Verona, Italy

⁷University of Verona, Verona, Italy

Presenting Author: Giovanni Savini

Synopsis

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References

1. Palombo M, Ianus A, Guerreri M, et al. SANDI: A compartment-based model for non-invasive apparent soma and neurite imaging by diffusion MRI. Neuroimage. 2020 Jul 15;215:116835. doi: 10.1016/j.neuroimage.2020.116835 [doi]

2. Jones DK, Alexander DC, Bowtell R, et al. Microstructural imaging of the human brain with a 'super-scanner': 10 key advantages of ultra-strong gradients for diffusion MRI. Neuroimage. 2018 Nov 15;182:8-38. doi: 10.1016/j.neuroimage.2018.05.047 [doi]

3. Ianuş A, Palombo M, Simões R, et al. Soma and Neurite Density Imaging (SANDI) characterizes microscopic differences between two glioma mouse model subtypes. Proceedings of 2023 ISMRM Annual Meeting. doi: 10.58530/2023/0268 [doi]

4. Schiavi S, Palombo M, Zacà D, et al. Mapping tissue microstructure across the human brain on a clinical scanner with soma and neurite density image metrics. Hum Brain Mapp. 2023 Sep;44(13):4792-4811. doi: 10.1002/hbm.26416 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/651-02-003