Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
402-03-008 ISMRM Abstract

Neurochemical Changes During Prefrontal High-Definition Transcranial Direct Current Stimulation: A Concurrent MRS Study

Primary: Neuro - Neuromodulation
Secondary: Interventional - MR-Guided Neuromodulation
402-03-008 · Metabolic Imaging and MR Spectroscopy: Methods and Application · Tuesday, 12 May, 1:40 PM–3:30 PM · Hall 1B
Keywords: Transcranial direct current stimulation Magnetic Resonance Spectroscopy Non-invasive Neuromodulation
Accepted
Siyuan Fang1,2, Gaiying Li 1,2, Yihui Cheng3, Yulin Wen1,2, Yupeng Wu1,2, Ying Tang1,2, Huifang He3, Yang Song4, Ying Shen3, Jianqi Li1,2
1Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China
2Institute of Magnetic Resonance and Molecular Imaging in Medicine, East China Normal University, Shanghai, China
3Department of Rehabilitation Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
4MR Scientific Marketing, Siemens Healthineers, Shanghai, China
Presenting Author: Gaiying Li

Synopsis

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References

1. Ren, C., S.R. Pagali, Z. Wang, et al. Transcranial electrical stimulation in treatment of depression: A systematic review and meta-analysis. JAMA Netw Open, 2025;8(6):e2516459. doi:10.1001/jamanetworkopen.2025.16459 [doi]
2. Guiomar, R., M. Sobral, L. Vanden Berghe, et al. Assessing tDCS efficacy in reducing negative symptoms in schizophrenia spectrum disorders: A systematic review and meta-analysis. Brain Stimul, 2025;18(6):1794-1806. doi:10.1016/j.brs.2025.09.011 [doi]
3. Hone-Blanchet, A., R.A. Edden, and S. Fecteau. Online effects of transcranial direct current stimulation in real time on human prefrontal and striatal metabolites. Biol Psychiatry, 2016;80(6):432-438. doi:10.1016/j.biopsych.2015.11.008 [doi]
4. Vural, G., A. Soldini, F. Padberg, et al. Exploring the effects of prefrontal transcranial direct current stimulation on brain metabolites: A concurrent tDCS-MRS study. Hum Brain Mapp, 2024;45(18):e70097. doi:10.1002/hbm.70097 [doi]
5. Dickler, M., C. Lenglos, E. Renauld, et al. Online effects of transcranial direct current stimulation on prefrontal metabolites in gambling disorder. Neuropharmacology, 2018;131:51-57. doi:10.1016/j.neuropharm.2017.12.002 [doi]
6. Edwards, D., M. Cortes, A. Datta, et al. Physiological and modeling evidence for focal transcranial electrical brain stimulation in humans: A basis for high-definition tDCS. Neuroimage, 2013;74:266-275. doi:10.1016/j.neuroimage.2013.01.042 [doi]
7. Bachtiar, V., A. Johnstone, A. Berrington, et al. Modulating regional motor cortical excitability with noninvasive brain stimulation results in neurochemical changes in bilateral motor cortices. J Neurosci, 2018;38(33):7327-7336. doi:10.1523/jneurosci.2853-17.2018 [doi]
8. Patel, H.J., S. Romanzetti, A. Pellicano, et al. Proton magnetic resonance spectroscopy of the motor cortex reveals long term GABA change following anodal transcranial direct current stimulation. Sci Rep, 2019;9(1):2807. doi:10.1038/s41598-019-39262-7 [doi]
9. Mugnol-Ugarte, L., T. Bortolini, B. Yao, et al. Transcranial electrical stimulation modulates emotional experience and metabolites in the prefrontal cortex in a donation task. Sci Rep, 2024;14(1):14271. doi:10.1038/s41598-024-64876-x [doi]
10. Masina, F., G. Arcara, E. Galletti, et al. Neurophysiological and behavioural effects of conventional and high definition tDCS. Sci Rep, 2021;11(1):7659. doi:10.1038/s41598-021-87371-z [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/402-03-008