361-04-009 ISMRM Abstract

Fluid Suppressed Amide Proton Transfer CEST imaging with “Inverse-Z minus One” weighting

Primary: Contrast Mechanisms - CEST / APT / NOE

Secondary: Acquisition & Reconstruction - Quantitative Imaging: relaxometry, multi-parametric, MR Fingerprinting, and synthetic MRI

361-04-009 · Advanced Neuroimaging with MRI: CEST and APT Techniques · Monday, 11 May, 2:45 PM–3:40 PM · Digital Posters Row B

Keywords: CEST & MT Contrast Mechanisms CEST / APT / NOE APT Brain tumor

Accepted

Mitsuharu Miyoshi¹, Ryuta ITO², Shotaro Fuchibe³, YOSHIMURA MASAHIRO², Yoshiyuki Watanabe⁴, Tetsuya Wakayama ¹

¹GE HealthCare, Hino, Japan

²Department of Radiology, Shiga University of Medical Science Hospital, Shiga, Japan

³Science and Technology Organization, GE HealthCare, Hino, Japan

⁴Department of Radiology, Shiga University of Medical Science, Shiga, Japan

Presenting Author: Tetsuya Wakayama

Synopsis

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References

1. Schüre JR, Casagranda S, Sedykh M, Liebig P, Papageorgakis C, Mancini L, Bisdas S, Nichelli L, Pinter N, Mechtler L, Jafari R, Boddaert N, Dangouloff-Ros V, Poujol J, Schmidt M, Doerfler A, Zaiss M. Fluid suppression in amide proton transfer-weighted (APTw) CEST imaging: New theoretical insights and clinical benefits. Magn Reson Med. 2024 April;91(4):1354–1367, doi:10.1002/mrm.29915 [doi]

2. Togao O, Keupp J, Yamashita K, Kikuchi K, Wada T, and Ishigami K. Amide proton transfer-weighted MRI of brain tumors with fluid & solid compartment corrections using background magnetization transfer effects. Proc. Intl. Soc. Mag. Reson. Med. 31 (2023) #2491.

3. Keupp J, Togao O. APTw-MRI with additional suppression of fluid compartments (necrosis) and noise reduction using rescaled MT-correcting CEST metrics. Proc. Intl. Soc. Mag. Reson. Med. 33 (2025) #2306.

4. Zaiss M, Xu J, Goerke S, Khan IS, Singer RJ, Gore JC, Gochberg DF, Bachert P. Inverse Z-spectrum analysis for spillover-, MT-, and T1-corrected steady-state pulsed CEST-MRI – application to pH-weighted MRI of acute stroke. NMR Biomed. 2014 March; 27(3): 240–252, doi:10.1002/nbm [doi]

5. Zhou J, Zaiss M, Knutsson L, Sun PZ, Ahn SS, Aime S, Bachert P, Blakeley JA, Cai K, Chappell MA, Chen M, Gochberg DF, Goerke S, Heo HY, Jiang S, Jin T, Kim SG, Laterra J, Paech D, Pagel MD, Park JE, Reddy R, Sakata A, Sartoretti-Schefer S, Sherry AD, Smith SA, Stanisz GJ, Sundgren PC, Togao O, Vandsburger M, Wen Z, Wu Y, Zhang Y, Zhu W, Zu Z, van Zijl PCM. Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors. Magnetic Resonance in Medicine. 2022;88(2):546–574. doi: 10.1002/mrm.29241 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/361-04-009